Reaction profile

The FDA adverse-event record for endocarditis

37 FDA adverse-event reports reference endocarditis (VeDDRA 210). See the species, breeds, and drugs most associated with it below.

37
reports citing this reaction
94.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
37
Total Reports
35
Deaths
94.6%
Death Rate

Species Most Affected

Dog 29
Cattle 5
Cat 2
Pig 1

Breeds Most Affected

Cattle (other) 3
Chihuahua 2
Dog (unknown) 2
Pointing Dog - Hungarian Short-haired (Vizsla) 2
Retriever - Labrador 2
Saint Bernard Dog 2
Maltese 2
Terrier (unspecified) 2
Shepherd Dog - German 1
Akita 1

Associated Drugs

Milbemycin Oxime + Spinosad 10
Spinosad 6
Monensin Sodium 3
Tulathromycin 2
Bovine Respiratory Syncytial Virus, 597-10 10Th Psg Strain 375; Bovine Viral Dia 2
Clostridium Chauvoei, Strain F, Lot No. 2-84; Clostridium Novyi, 8296, Kb; Clost 2
Oclacitinib Maleate 2
Selamectin 2
Afoxolaner 2
Ketamine 2
Fluralaner Chew Tablets 2
Moxidectin 2
Fluralaner 13.64% 12-Week Chew 2
Milbemycin Oxime + Lufenuron 1
Milbemycin Oxime 1
Ivermectin 1
Ivermectin + Pyrantel Pamoate 1
Rabies Vaccine 1
Fvrcp Vaccine 1
Felv Viral Antigen Vaccine 1

Endocarditis Reaction Insights

37 reports name Endocarditis; 35 recorded a death outcome (94.6% of reported events, not a population-level mortality rate). VeDDRA code: 210.

By species: Dog (29 reports), Cattle (5 reports), Cat (2 reports). By breed: Cattle (other) (3), Chihuahua (2), Dog (unknown) (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (10 reports), Spinosad (6 reports), Monensin Sodium (3 reports), Tulathromycin (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.