Reaction profile

The FDA adverse-event record for endocarditis

37 FDA reports name endocarditis, a lower-volume reaction in the CVM extract (VeDDRA 210). Plate stamps and neighbourhood peers follow.

#1895 of 2,481
by report volume (all reactions)
37
reports citing this reaction
94.6%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Endocarditis has 37 reports now versus 37 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Endocarditis changes

FDA AER · VeDDRA plate

Code 210 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 37 reports
  • DEATH-HOT 94.6%
  • LOWER-Q #1895/2481
  • PHOTO-FINISH Blistering of mouth
  • SPECIES-DOG Dog · 29
  • DRUG-LEAD Milbemycin Oxime… · 10
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Blistering of mouth (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Endocarditis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Blistering of mouth · near37CARBON DIOXIDE HIGH,… · near37Cartilage degeneration · near37Cleft palate · near37Endocarditis · this reaction37Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Endocarditis

Endocarditis: high death-coded share in the FDA AER plate

Signature read: Endocarditis's 94.6% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 37 named reports in the openFDA extract. Death-coded share is upper-third: 35 of 37 reports (94.6% of named reports). Nearest volume peer: Blistering of mouth (±0 reports). Lead species Dog (29). Lead co-reported drug Milbemycin Oxime + Spinosad (10).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 29
Cattle 5
Cat 2
Pig 1

Breeds Most Affected

Cattle (other) 3
Chihuahua 2
Dog (unknown) 2
Pointing Dog - Hungarian Short-haired (Vizsla) 2
Retriever - Labrador 2
Saint Bernard Dog 2
Maltese 2
Terrier (unspecified) 2
Shepherd Dog - German 1
Akita 1

Associated Drugs

Milbemycin Oxime + Spinosad 10
Spinosad 6
Monensin Sodium 3
Tulathromycin 2
Bovine Respiratory Syncytial Virus, 597-10 10Th Psg Strain 375; Bovine Viral Dia 2
Clostridium Chauvoei, Strain F, Lot No. 2-84; Clostridium Novyi, 8296, Kb; Clost 2
Oclacitinib Maleate 2
Selamectin 2
Afoxolaner 2
Ketamine 2
Moxidectin 2
Fluralaner Chew Tablets 2
Fluralaner 13.64% 12-Week Chew 2
Milbemycin Oxime + Lufenuron 1
Milbemycin Oxime 1
Ivermectin 1
Ivermectin + Pyrantel Pamoate 1
Rabies Vaccine 1
Fvrcp Vaccine 1
Felv Viral Antigen Vaccine 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Endocarditis (#1895 of 2,481 by report volume); death-coded 94.6%. PlainBreed reaction plate · death-coded share stamp 94.6% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →