Reaction profile

The FDA adverse-event record for elevated c-reactive protein

27 FDA reports name elevated c-reactive protein, a lower-volume reaction in the CVM extract (VeDDRA 2267). Plate stamps and neighbourhood peers follow.

#2040 of 2,481
by report volume (all reactions)
27
reports citing this reaction
25.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Elevated C-reactive protein has 27 reports now versus 16 in that prior snapshot: 11 more (68.8%).

Report change
+11
Death-coded reports
+4
Death-coded share
+7.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Elevated C-reactive protein changes

FDA AER · VeDDRA plate

Code 2267 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 27 reports
  • DEATH-HOT 25.9%
  • LOWER-Q #2040/2481
  • PHOTO-FINISH Abortion spontaneous
  • SPECIES-DOG Dog · 27
  • DRUG-LEAD Meloxicam · 5
  • DESK-WIDE 17 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abortion spontaneous (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Elevated C-reactive protein

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abortion spontaneous · near27Aplastic anaemia · near27Cyanotic spots/blotch… · near27Cyst rupture NOS · near27Elevated C-reactive p… · thi…27Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Elevated C-reactive protein

Elevated C-reactive protein: high death-coded share in the FDA AER plate

Signature read: 27 reports place Elevated C-reactive protein in the lower third of FDA AER volume (#2040 of 2,481). Report volume is lower-third scale: 27 named reports in the openFDA extract. Death-coded share is upper-third: 7 of 27 reports (25.9% of named reports). Nearest volume peer: Abortion spontaneous (±0 reports). Lead species Dog (27). Lead co-reported drug Meloxicam (5).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 27

Breeds Most Affected

Dachshund - Miniature 4
Retriever - Labrador 4
Dog (unknown) 3
Crossbred Canine/dog 3
Shih Tzu 1
Bulldog 1
Corgi - Welsh Cardigan 1
Terrier - Cairn 1
Mastiff (unspecified) 1
Beagle 1

Associated Drugs

Meloxicam 5
Robenacoxib 5
Rabies Vaccine 4
Ilunocitinib 4
Isoflurane 4
Bedinvetmab 4
Firocoxib 57 Mg Chewable 2
Fluralaner 13.64% 12-Week Chew 2
Buprenorphine 2
Propofol 2
Carprofen 2
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 2
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str 2
Bordetella Bronchiseptica, Strain 78-9159 2
Canine Influenza Virus H3N2;Canine Influenza Virus H3N8 2
Rabies Virus, Kv 2
Ivermectin 2
Fluralaner 2
Mupirocin 2
Grapiprant 2

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Elevated C-reactive protein (#2040 of 2,481 by report volume); death-coded 25.9%. PlainBreed reaction plate · report volume stamp 27 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →