Reaction profile

The FDA adverse-event record for diabetes insipidus

41 FDA adverse-event reports reference diabetes insipidus (VeDDRA 401). See the species, breeds, and drugs most associated with it below.

41
reports citing this reaction
19.5%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
41
Total Reports
8
Deaths
19.5%
Death Rate

Species Most Affected

Dog 40
Cat 1

Breeds Most Affected

Boxer (German Boxer) 6
Retriever - Labrador 4
Beagle 2
Crossbred Canine/dog 2
Collie - Border 2
Terrier - Boston 2
Siberian Husky 2
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 2
Domestic (unspecified) 1
Pointing Dog - German Short-haired 1

Associated Drugs

Trilostane 34
Oclacitinib Maleate 6
Milbemycin Oxime + Praziquantel 5
Bedinvetmab 4
Fluralaner Chew Tablets 3
Grapiprant 3
Anti-Il31 Mab Mcs Lot #1283563 3
Rabacfosadine Succinate 2
Levothyroxine 2
Thyroid Supplement 2
Tramadol 2
Gabapentin 2
Nitenpyram 1
Amoxicillin 500 Mg 1
Soloxine 1
Spinosad 1
Fipronil + (S)-Methoprene 1
Imidacloprid + Moxidectin 1
Fluralaner 1
Methocarbamol 1

Diabetes insipidus Reaction Insights

41 reports name Diabetes insipidus; 8 recorded a death outcome (19.5% of reported events, not a population-level mortality rate). VeDDRA code: 401.

By species: Dog (40 reports), Cat (1 reports). By breed: Boxer (German Boxer) (6), Retriever - Labrador (4), Beagle (2).

Most co-reported drugs: Trilostane (34 reports), Oclacitinib Maleate (6 reports), Milbemycin Oxime + Praziquantel (5 reports), Bedinvetmab (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.