Reaction profile

The FDA adverse-event record for deterioration of muscle function

21 FDA reports name deterioration of muscle function, a lower-volume reaction in the CVM extract (VeDDRA 1409). Plate stamps and neighbourhood peers follow.

#2139 of 2,481
by report volume (all reactions)
21
reports citing this reaction
52.4%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Deterioration of muscle function has 21 reports now versus 20 in that prior snapshot: 1 more (5.0%).

Report change
+1
Death-coded reports
+1
Death-coded share
+2.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Deterioration of muscle function changes

FDA AER · VeDDRA plate

Code 1409 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 21 reports
  • DEATH-HOT 52.4%
  • LOWER-Q #2139/2481
  • PHOTO-FINISH Chewing - pruritus
  • SPECIES-DOG Dog · 16
  • DRUG-LEAD Bedinvetmab · 5
  • DESK-WIDE 13 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Chewing - pruritus (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Deterioration of muscle function

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Chewing - pruritus · near21Deterioration of musc… · thi…21External teat disorder · near21Heart disorder aggrav… · near21Hyperparathyroidism · near21Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Deterioration of muscle function

Deterioration of muscle function: high death-coded share in the FDA AER plate

Signature read: Deterioration of muscle function's 52.4% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 21 named reports in the openFDA extract. Death-coded share is upper-third: 11 of 21 reports (52.4% of named reports). Nearest volume peer: Chewing - pruritus (±0 reports). Lead species Dog (16). Lead co-reported drug Bedinvetmab (5).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 16
Cat 4
Horse 1

Breeds Most Affected

Retriever - Labrador 4
Domestic Shorthair 3
Dog (unknown) 2
Poodle - Standard 2
Dachshund (unspecified) 2
Collie - Border 1
Poodle - Miniature 1
Spitz - American Eskimo Dog 1
Boxer (German Boxer) 1
Crossbred Canine/dog 1

Associated Drugs

Bedinvetmab 5
Gabapentin 5
Galliprant 4
Sarolaner 3
Cyclosporine (Ophthalmic) 3
Pilocarpine 3
Milbemycin Oxime + Spinosad 2
Afoxolaner 2
Enrofloxacin 2
Alprazolam 2
Maropitant Citrate 2
Fluid Therapy 2
Pain Meds (Unknown) 2
Bacitracin + Neomycin + Polymyxin B 2
Eye Ointment (Unknown) 2
Pilocarpine Ophthalmic 2
Ivermectin 1
Unspecified Ocular Medications 1
Levetiracetam 1
Lotilaner 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Deterioration of muscle function (#2139 of 2,481 by report volume); death-coded 52.4%. PlainBreed reaction plate · death-coded share stamp 52.4% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →