Reaction profile

The FDA adverse-event record for deterioration of muscle function

20 FDA adverse-event reports reference deterioration of muscle function (VeDDRA 1409). See the species, breeds, and drugs most associated with it below.

20
reports citing this reaction
50.0%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
20
Total Reports
10
Deaths
50.0%
Death Rate

Species Most Affected

Dog 16
Cat 3
Horse 1

Breeds Most Affected

Retriever - Labrador 4
Dog (unknown) 2
Domestic Shorthair 2
Poodle - Standard 2
Dachshund (unspecified) 2
Collie - Border 1
Poodle - Miniature 1
Spitz - American Eskimo Dog 1
Boxer (German Boxer) 1
Crossbred Canine/dog 1

Associated Drugs

Bedinvetmab 5
Gabapentin 5
Galliprant 4
Sarolaner 3
Cyclosporine (Ophthalmic) 3
Pilocarpine 3
Milbemycin Oxime + Spinosad 2
Afoxolaner 2
Enrofloxacin 2
Alprazolam 2
Maropitant Citrate 2
Fluid Therapy 2
Pain Meds (Unknown) 2
Bacitracin + Neomycin + Polymyxin B 2
Eye Ointment (Unknown) 2
Pilocarpine Ophthalmic 2
Ivermectin 1
Unspecified Ocular Medications 1
Levetiracetam 1
Lotilaner 1

Deterioration of muscle function Reaction Insights

20 reports name Deterioration of muscle function; 10 recorded a death outcome (50.0% of reported events, not a population-level mortality rate). VeDDRA code: 1409.

By species: Dog (16 reports), Cat (3 reports), Horse (1 reports). By breed: Retriever - Labrador (4), Dog (unknown) (2), Domestic Shorthair (2).

Most co-reported drugs: Bedinvetmab (5 reports), Gabapentin (5 reports), Galliprant (4 reports), Sarolaner (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.