Reaction profile

The FDA adverse-event record for cyanotic spots/blotchy skin

25 FDA adverse-event reports reference cyanotic spots/blotchy skin (VeDDRA 2497). See the species, breeds, and drugs most associated with it below.

25
reports citing this reaction
12.0%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
25
Total Reports
3
Deaths
12.0%
Death Rate

Species Most Affected

Dog 23
Human 1
Cat 1

Breeds Most Affected

Retriever - Golden 2
Terrier - Yorkshire 2
Crossbred Canine/dog 2
Terrier - Bull - American Pit 2
Chihuahua 2
Retriever - Labrador 2
Shepherd Dog - German 2
Spitz - German Pomeranian 1
Havanese 1
Terrier - Jack Russell 1

Associated Drugs

Oclacitinib Maleate 4
Moxidectin 3
Carprofen 3
Joint Supplement 3
Afoxolaner 2
Sarolaner 2
Atipamezole Hydrochloride 2
Maropitant Citrate 2
Butorphanol Tartrate 2
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 2
Dexamethasone 2
Bupivacaine 2
Dexmedetomidine Hydrochloride 2
Fluralaner 13.64% 12-Week Chew 2
Lotilaner 2
Ivermectin + Pyrantel As Pamoate Salt 1
Genta/Momet/Clotrim Ear Oint 1
Milbemycin Oxime 1
Mirtazapine 1
Bordetella Bronchiseptica, Strain 78-9159 1

Cyanotic spots/blotchy skin Reaction Insights

25 reports name Cyanotic spots/blotchy skin; 3 recorded a death outcome (12.0% of reported events, not a population-level mortality rate). VeDDRA code: 2497.

By species: Dog (23 reports), Human (1 reports), Cat (1 reports). By breed: Retriever - Golden (2), Terrier - Yorkshire (2), Crossbred Canine/dog (2).

Most co-reported drugs: Oclacitinib Maleate (4 reports), Moxidectin (3 reports), Carprofen (3 reports), Joint Supplement (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.