Reaction profile

The FDA adverse-event record for cutaneous emphysema

40 FDA adverse-event reports reference cutaneous emphysema (VeDDRA 1202). See the species, breeds, and drugs most associated with it below.

40
reports citing this reaction
40.0%
death-coded share
Dog
most-affected species
Dinoprost Tromethamine
most-associated drug
Verify with FDA CVM →
40
Total Reports
16
Deaths
40.0%
Death Rate

Species Most Affected

Dog 16
Cat 13
Cattle 10
Horse 1

Breeds Most Affected

Domestic Shorthair 9
Cattle (other) 5
Jersey 2
Domestic Longhair 2
Boxer (German Boxer) 2
Holstein-Friesian also known as Holstein 1
Shih Tzu 1
Aberdeen Angus 1
Maine Coon 1
Dog (unknown) 1

Associated Drugs

Dinoprost Tromethamine 7
Cefovecin 6
Maropitant Citrate 5
Robenacoxib 4
Clostridium Novyi, 8296;Clostridium Perfringens Type C, Pc8 4
Dexamethasone 3
Rabies Vaccine 2
Diphenhydramine Hcl 2
Dexmedetomidine Hydrochloride 2
Selamectin 2
Butorphanol Tartrate 2
Ketamine 2
Isoflurane 2
Moxidectin 2
Bupivacaine 2
Carprofen 2
Prednisone 2
Anesthetic 2
Praziquantel And Pyrantel Pamoate 1
Ceftiofur Crystalline Free Acid 1

Cutaneous emphysema Reaction Insights

40 reports name Cutaneous emphysema; 16 recorded a death outcome (40.0% of reported events, not a population-level mortality rate). VeDDRA code: 1202.

By species: Dog (16 reports), Cat (13 reports), Cattle (10 reports). By breed: Domestic Shorthair (9), Cattle (other) (5), Jersey (2).

Most co-reported drugs: Dinoprost Tromethamine (7 reports), Cefovecin (6 reports), Maropitant Citrate (5 reports), Robenacoxib (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.