Reaction profile

The FDA adverse-event record for cushings disease - pituitary dependent

Name: Cushings disease - pituitary dependent - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

26 FDA reports name cushings disease - pituitary dependent, a lower-volume reaction in the CVM extract (VeDDRA 381). Plate stamps and neighbourhood peers follow.

#2051 of 2,481
by report volume (all reactions): 26
reports citing this reaction: 11.5%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cushings disease - pituitary dependent has 26 reports now versus 23 in that prior snapshot: 3 more (13.0%).

Report change: +3
Death-coded reports: +0
Death-coded share: −1.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cushings disease - pituitary dependent changes

FDA AER · VeDDRA plate

Code 381 VOL-TRACE

VOL-TRACE · DEATH-ELEV · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 26 reports
DEATH-ELEV 11.5%
LOWER-Q #2051/2481
PHOTO-FINISH Dermoid cyst
SPECIES-DOG Dog · 21
DRUG-LEAD Trilostane · 4
DESK-WIDE 18 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Dermoid cyst (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Cushings disease - pituitary dependent

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Cushings disease - pituitary dependent

What the FDA AER plate says about Cushings disease - pituitary dependent

Signature read: 26 reports place Cushings disease - pituitary dependent in the lower third of FDA AER volume (#2051 of 2,481). Report volume is lower-third scale: 26 named reports in the openFDA extract. 3 of 26 reports were death-coded (11.5% of named reports, not a population mortality rate). Nearest volume peer: Dermoid cyst (±0 reports). Lead species Dog (21). Lead co-reported drug Trilostane (4).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Trilostane appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 21

Horse 5

Breeds Most Affected

Beagle 4

Retriever - Labrador 4

Terrier - Boston 2

Spitz - American Eskimo Dog 2

Maltese 1

Dog (unknown) 1

Pointing Dog - Hungarian Short-haired (Vizsla) 1

Siberian Husky 1

Havanese 1

Corgi - Welsh Pembroke 1

Associated Drugs

Trilostane 4

Bedinvetmab 4

Grapiprant 3

Pergolide Mesylate 3

Milbemycin Oxime + Spinosad 2

Polysulfated Glycosaminoglycan 2

Cyclosporine 2

Pyrantel Pamoate;Sarolaner 2

Detomidine Hydrochloride 2

Butorphanol Tartrate 2

Human Insulin 2

Cyclosporine Ointment 2

Eggshell Membrane Krill Oil Hyaluronic Acid 2

Unspecified Amlodipine 2

Unspecified Enalapril 2

Unspecified Carprofen 2

Unspecified Gabapentin 2

Amoxicillin Clavulanate 2

Unspecified Ciprofloxacin 2

Unspecified Enrofloxacin 2

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cushings disease - pituitary dependent (#2051 of 2,481 by report volume); death-coded 11.5%. PlainBreed reaction plate · report volume stamp 26 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →