Reaction profile

The FDA adverse-event record for cryptorchidism

16 FDA reports name cryptorchidism, a lower-volume reaction in the CVM extract (VeDDRA 754). Plate stamps and neighbourhood peers follow.

#2265 of 2,481
by report volume (all reactions)
16
reports citing this reaction
50.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cryptorchidism has 16 reports now versus 16 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cryptorchidism changes

FDA AER · VeDDRA plate

Code 754 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 16 reports
  • DEATH-HOT 50.0%
  • BOTTOM-DECILE #2265/2481
  • PHOTO-FINISH Abdominal transudate
  • SPECIES-DOG Dog · 16
  • DRUG-LEAD Milbemycin Oxime… · 8
  • DESK-WIDE 12 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abdominal transudate (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Cryptorchidism

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abdominal transudate · near16Abnormal rectal palpa… · near16AMMONIA INCREASED, BL… · near16Application site gran… · near16Cryptorchidism · this reacti…16Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Cryptorchidism

Cryptorchidism: high death-coded share in the FDA AER plate

Signature read: 16 reports place Cryptorchidism in the lower third of FDA AER volume (#2265 of 2,481). Report volume is lower-third scale: 16 named reports in the openFDA extract. Death-coded share is upper-third: 8 of 16 reports (50.0% of named reports). Nearest volume peer: Abdominal transudate (±0 reports). Lead species Dog (16). Lead co-reported drug Milbemycin Oxime + Spinosad (8).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 16

Breeds Most Affected

Terrier - Boston 3
Shepherd Dog - German 2
Beagle 2
Terrier - Yorkshire 1
Pug 1
Corgi - Welsh Pembroke 1
Rottweiler 1
Dog (other) 1
Bulldog - French 1
Boxer (German Boxer) 1

Associated Drugs

Milbemycin Oxime + Spinosad 8
Fluralaner Chew Tablets 5
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 2
Gabapentin 2
Ampicillin Sodium/Sulbactam Sodium 2
Fluid Therapy 2
Famotidine 2
Maropitant Citrate 2
Spinosad 1
Fluralaner Spot-On Solution 1
Lotilaner 1
Bordetella Bronchiseptica Vaccine, Avirulent Live Culture 1
Milbemycin Oxime + Praziquantel 1
Capromorelin Tartrate 1
Amoxicillin + Clavulanic Acid 1
Methadone 1
Metronidazole 1
Enrofloxacin 1
Buprenorphine 1
Capromorelin 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cryptorchidism (#2265 of 2,481 by report volume); death-coded 50.0%. PlainBreed reaction plate · report volume stamp 16 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →