Reaction profile

The FDA adverse-event record for cryptorchidism

16 FDA adverse-event reports reference cryptorchidism (VeDDRA 754). See the species, breeds, and drugs most associated with it below.

16
reports citing this reaction
50.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
16
Total Reports
8
Deaths
50.0%
Death Rate

Species Most Affected

Dog 16

Breeds Most Affected

Terrier - Boston 3
Shepherd Dog - German 2
Beagle 2
Terrier - Yorkshire 1
Pug 1
Corgi - Welsh Pembroke 1
Rottweiler 1
Dog (other) 1
Bulldog - French 1
Boxer (German Boxer) 1

Associated Drugs

Milbemycin Oxime + Spinosad 8
Fluralaner Chew Tablets 5
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 2
Gabapentin 2
Ampicillin Sodium/Sulbactam Sodium 2
Fluid Therapy 2
Famotidine 2
Maropitant Citrate 2
Spinosad 1
Fluralaner Spot-On Solution 1
Lotilaner 1
Bordetella Bronchiseptica Vaccine, Avirulent Live Culture 1
Milbemycin Oxime + Praziquantel 1
Capromorelin Tartrate 1
Amoxicillin + Clavulanic Acid 1
Methadone 1
Metronidazole 1
Enrofloxacin 1
Buprenorphine 1
Capromorelin 1

Cryptorchidism Reaction Insights

16 reports name Cryptorchidism; 8 recorded a death outcome (50.0% of reported events, not a population-level mortality rate). VeDDRA code: 754.

By species: Dog (16 reports). By breed: Terrier - Boston (3), Shepherd Dog - German (2), Beagle (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (8 reports), Fluralaner Chew Tablets (5 reports), Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (2 reports), Gabapentin (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.