Reaction profile

The FDA adverse-event record for cranial nerve paralysis

12 FDA adverse-event reports reference cranial nerve paralysis (VeDDRA 1150). See the species, breeds, and drugs most associated with it below.

12
reports citing this reaction
8.3%
death-coded share
Dog
most-affected species
Ivermectin + Pyrantel
most-associated drug
Verify with FDA CVM →
12
Total Reports
1
Deaths
8.3%
Death Rate

Species Most Affected

Dog 10
Horse 1
Cat 1

Breeds Most Affected

Retriever - Labrador 3
Retriever - Golden 2
Paint 1
Crossbred Canine/dog 1
Terrier - West Highland White 1
Chihuahua 1
Shepherd (unspecified) 1
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1
Domestic Shorthair 1

Associated Drugs

Ivermectin + Pyrantel 2
Oxybendazole 1
Milbemycin Oxime + Spinosad 1
Fipronil 1
Fluralaner Chew Tablets 1
Canine B Burgdorferi *2 Alu Kb 1
Canine Lepto*4(Orig S-P Us) Kb 1
Canine Da2Ppv (Orig S-P Us) Lv 1
Milbemycin Oxime 1
Ivermectin 1
Afoxolaner 1
Sarolaner 1
Genta/Momet/Clotrim Ear Oint 1
Trilostane 1
Fluralaner Spot-On Solution 1
Carprofen 1
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 1
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 1
Bordetella Bronchiseptica, Strain 78-9159 1
Ampicillin 1

Cranial nerve paralysis Reaction Insights

12 reports name Cranial nerve paralysis; 1 recorded a death outcome (8.3% of reported events, not a population-level mortality rate). VeDDRA code: 1150.

By species: Dog (10 reports), Horse (1 reports), Cat (1 reports). By breed: Retriever - Labrador (3), Retriever - Golden (2), Paint (1).

Most co-reported drugs: Ivermectin + Pyrantel (2 reports), Oxybendazole (1 reports), Milbemycin Oxime + Spinosad (1 reports), Fipronil (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.