Reaction profile

The FDA adverse-event record for cramp nos

19 FDA reports name cramp nos, a lower-volume reaction in the CVM extract (VeDDRA 2841). Plate stamps and neighbourhood peers follow.

#2180 of 2,481
by report volume (all reactions)
19
reports citing this reaction
5.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Cramp NOS has 19 reports now versus 15 in that prior snapshot: 4 more (26.7%).

Report change
+4
Death-coded reports
+0
Death-coded share
−1.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Cramp NOS changes

FDA AER · VeDDRA plate

Code 2841 VOL-TRACE

VOL-TRACE · DEATH-PAR · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 19 reports
  • DEATH-PAR 5.3%
  • LOWER-Q #2180/2481
  • PHOTO-FINISH Adaptor, damaged
  • SPECIES-DOG Dog · 13
  • DRUG-LEAD Fluralaner 13.64%… · 3
  • DESK-WIDE 12 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Adaptor, damaged (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Cramp NOS

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Adaptor, damaged · near19Amaurosis (see also P… · near19Anhidrosis · near19Cholelithiasis · near19Cramp NOS · this reaction19Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Cramp NOS

Cramp NOS: low death-coded share in the FDA AER plate

Signature read: 19 reports place Cramp NOS in the lower third of FDA AER volume (#2180 of 2,481). Report volume is lower-third scale: 19 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 19 reports (5.3% of named reports). Nearest volume peer: Adaptor, damaged (±0 reports). Lead species Dog (13). Lead co-reported drug Fluralaner 13.64% 12-Week Chew (3).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Fluralaner 13.64% 12-Week Chew appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 13
Horse 6

Breeds Most Affected

Shepherd Dog - Australian 3
Spitz - German Pomeranian 2
Retriever - Golden 2
Paint 2
Horse (unknown) 2
Thoroughbred 2
Terrier - Rat 1
Sheepdog - Shetland 1
Poodle - Miniature 1
Spaniel - King Charles Cavalier 1

Associated Drugs

Fluralaner 13.64% 12-Week Chew 3
Pyrantel Pamoate;Sarolaner 3
Lotilaner 1
Imidacloprid, Flumethrin 1
Cefovecin Sodium 1
Nitenpyram 1
Unspecified Pimobendan 1
Unspecified Enalapril 1
Polysulfated Glycosaminoglycan 1
Grapiprant 1
S-Adenosylmethionine + Silybin 1
Gabapentin 1
Probiotic Supplement 1
Milbemycin/Lufenuron/Pzq Chew 1
Dinoprost Tromethamine 1
Ceftiofur Crystalline Free Acid 1
Clodronate Disodium 1
Firocoxib 1
Fluralaner 5.46% 1-Month Chew 1
Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Cramp NOS (#2180 of 2,481 by report volume); death-coded 5.3%. PlainBreed reaction plate · report volume stamp 19 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →