Reaction profile

The FDA adverse-event record for cramp nos

15 FDA adverse-event reports reference cramp nos (VeDDRA 2841). See the species, breeds, and drugs most associated with it below.

15
reports citing this reaction
6.7%
death-coded share
Dog
most-affected species
Fluralaner 13.64% 12-Week Chew
most-associated drug
Verify with FDA CVM →
15
Total Reports
1
Deaths
6.7%
Death Rate

Species Most Affected

Dog 10
Horse 5

Breeds Most Affected

Shepherd Dog - Australian 3
Spitz - German Pomeranian 2
Thoroughbred 2
Horse (unknown) 2
Retriever - Golden 1
Paint 1
Terrier - Rat 1
Sheepdog - Shetland 1
Poodle - Miniature 1
Spaniel - King Charles Cavalier 1

Associated Drugs

Fluralaner 13.64% 12-Week Chew 3
Lotilaner 1
Imidacloprid, Flumethrin 1
Cefovecin Sodium 1
Nitenpyram 1
Unspecified Pimobendan 1
Unspecified Enalapril 1
Polysulfated Glycosaminoglycan 1
Grapiprant 1
S-Adenosylmethionine + Silybin 1
Gabapentin 1
Probiotic Supplement 1
Milbemycin/Lufenuron/Pzq Chew 1
Ceftiofur Crystalline Free Acid 1
Dinoprost Tromethamine 1
Pyrantel Pamoate;Sarolaner 1
Clodronate Disodium 1
Firocoxib 1
Fluralaner 5.46% 1-Month Chew 1
Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate 1

Cramp NOS Reaction Insights

15 reports name Cramp NOS; 1 recorded a death outcome (6.7% of reported events, not a population-level mortality rate). VeDDRA code: 2841.

By species: Dog (10 reports), Horse (5 reports). By breed: Shepherd Dog - Australian (3), Spitz - German Pomeranian (2), Thoroughbred (2).

Most co-reported drugs: Fluralaner 13.64% 12-Week Chew (3 reports), Lotilaner (1 reports), Imidacloprid, Flumethrin (1 reports), Cefovecin Sodium (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.