Reaction profile

The FDA adverse-event record for conjunctival irritation

46 FDA adverse-event reports reference conjunctival irritation (VeDDRA 1394). See the species, breeds, and drugs most associated with it below.

46
reports citing this reaction
2.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
46
Total Reports
1
Deaths
2.2%
Death Rate

Species Most Affected

Dog 40
Cat 5
Horse 1

Breeds Most Affected

Boxer (German Boxer) 4
Terrier - Rat 4
Spaniel - Cocker American 3
Domestic Shorthair 3
Terrier - Boston 2
Dachshund (unspecified) 2
Terrier (unspecified) 2
Crossbred Canine/dog 2
Shepherd Dog - Australian 1
Collie - Rough-haired 1

Associated Drugs

Milbemycin Oxime + Spinosad 7
Maropitant Citrate 5
Bordetella Vaccine 3
Oclacitinib Maleate 3
Robenacoxib 3
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 3
Lufenuron + Milbemycin Oxime 2
Milbemcyin Oxime, Lufenuron, Praziquantel 2
Polysulfated Glycosaminoglycan 2
Deracoxib 2
Afoxolaner 68 Mg Chewable Tablets 2
Carprofen 2
Afoxolaner 2
Ivermectin + Pyrantel As Pamoate Salt 2
Fluralaner Chew Tablets 2
Buprenorphine 2
Bupivacaine 2
Insulin Injectable Vial 2
Phytosphingosine Hydrochloride 2
Distemper Vaccine 2

Conjunctival irritation Reaction Insights

46 reports name Conjunctival irritation; 1 recorded a death outcome (2.2% of reported events, not a population-level mortality rate). VeDDRA code: 1394.

By species: Dog (40 reports), Cat (5 reports), Horse (1 reports). By breed: Boxer (German Boxer) (4), Terrier - Rat (4), Spaniel - Cocker American (3).

Most co-reported drugs: Milbemycin Oxime + Spinosad (7 reports), Maropitant Citrate (5 reports), Bordetella Vaccine (3 reports), Oclacitinib Maleate (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.