Reaction profile

The FDA adverse-event record for conjunctival irritation

46 FDA reports name conjunctival irritation, a lower-volume reaction in the CVM extract (VeDDRA 1394). Plate stamps and neighbourhood peers follow.

#1782 of 2,481
by report volume (all reactions)
46
reports citing this reaction
2.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Conjunctival irritation has 46 reports now versus 46 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Conjunctival irritation changes

FDA AER · VeDDRA plate

Code 1394 VOL-TRACE

VOL-TRACE · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 46 reports
  • DEATH-LOW 2.2%
  • MID-PACK #1782/2481
  • PHOTO-FINISH Barbering
  • SPECIES-DOG Dog · 40
  • DRUG-LEAD Milbemycin Oxime… · 7
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Barbering (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Conjunctival irritation

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Barbering · near46Conjunctival irritati… · thi…46Gingival erythema · near46Nervousness · near46NT - endocardiosis · near46Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Conjunctival irritation

Conjunctival irritation: low death-coded share in the FDA AER plate

Signature read: 1 death-coded reports is a thin tail count for Conjunctival irritation in the CVM extract. Report volume is lower-third scale: 46 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 46 reports (2.2% of named reports). Nearest volume peer: Barbering (±0 reports). Lead species Dog (40). Lead co-reported drug Milbemycin Oxime + Spinosad (7).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 40
Cat 5
Horse 1

Breeds Most Affected

Boxer (German Boxer) 4
Terrier - Rat 4
Spaniel - Cocker American 3
Domestic Shorthair 3
Terrier - Boston 2
Dachshund (unspecified) 2
Terrier (unspecified) 2
Crossbred Canine/dog 2
Shepherd Dog - Australian 1
Collie - Rough-haired 1

Associated Drugs

Milbemycin Oxime + Spinosad 7
Maropitant Citrate 5
Bordetella Vaccine 3
Oclacitinib Maleate 3
Robenacoxib 3
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 3
Lufenuron + Milbemycin Oxime 2
Milbemcyin Oxime, Lufenuron, Praziquantel 2
Polysulfated Glycosaminoglycan 2
Deracoxib 2
Carprofen 2
Afoxolaner 68 Mg Chewable Tablets 2
Afoxolaner 2
Ivermectin + Pyrantel As Pamoate Salt 2
Fluralaner Chew Tablets 2
Buprenorphine 2
Bupivacaine 2
Insulin Injectable Vial 2
Phytosphingosine Hydrochloride 2
Distemper Vaccine 2

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Conjunctival irritation (#1782 of 2,481 by report volume); death-coded 2.2%. PlainBreed reaction plate · death-coded report count stamp 1 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →