Reaction profile

The FDA adverse-event record for clonic seizure

29 FDA adverse-event reports reference clonic seizure (VeDDRA 1125). See the species, breeds, and drugs most associated with it below.

29
reports citing this reaction
13.8%
death-coded share
Dog
most-affected species
Pyrantel Pamoate;Sarolaner
most-associated drug
Verify with FDA CVM →
29
Total Reports
4
Deaths
13.8%
Death Rate

Species Most Affected

Dog 25
Cat 3
Pig 1

Breeds Most Affected

Retriever - Golden 3
Schnauzer (unspecified) 3
Boxer (German Boxer) 2
Pug 2
Retriever - Labrador 2
Sheepdog - Shetland 2
Abyssinian cat 1
Corso Dog 1
Siamese 1
Dachshund (unspecified) 1

Associated Drugs

Pyrantel Pamoate;Sarolaner 5
Milbemycin Oxime + Spinosad 4
Sarolaner 4
Solliquin 3
Carprofen 2
Afoxolaner 2
Galliprant 2
Incurin 2
Cyclosporine A 1
No Concurrent Products Given 1
Afoxolaner 136 Mg Chewable Tablets 1
Alfaxalone 1
Cefovecin 1
Lidocaine 1
Buprenorphine 1
Ivermectin + Pyrantel 1
Fluralaner Chew Tablets 1
Ivermectin 1
Glucosamine Hcl, Chondroitin Sulfate & Manganese 1
Milbemycin Oxime + Praziquantel 1

Clonic seizure Reaction Insights

29 reports name Clonic seizure; 4 recorded a death outcome (13.8% of reported events, not a population-level mortality rate). VeDDRA code: 1125.

By species: Dog (25 reports), Cat (3 reports), Pig (1 reports). By breed: Retriever - Golden (3), Schnauzer (unspecified) (3), Boxer (German Boxer) (2).

Most co-reported drugs: Pyrantel Pamoate;Sarolaner (5 reports), Milbemycin Oxime + Spinosad (4 reports), Sarolaner (4 reports), Solliquin (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.