Reaction profile

The FDA adverse-event record for clonic muscle spasm

Name: Clonic muscle spasm - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

20 FDA reports name clonic muscle spasm, a lower-volume reaction in the CVM extract (VeDDRA 1139). Plate stamps and neighbourhood peers follow.

#2159 of 2,481
by report volume (all reactions): 20
reports citing this reaction: 10.0%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Clonic muscle spasm has 20 reports now versus 20 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Clonic muscle spasm changes

FDA AER · VeDDRA plate

Code 1139 VOL-TRACE

VOL-TRACE · DEATH-ELEV · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 20 reports
DEATH-ELEV 10.0%
LOWER-Q #2159/2481
PHOTO-FINISH Agalactia
SPECIES-DOG Dog · 16
DRUG-LEAD Spinosad · 3
DESK-WIDE 16 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Agalactia (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Clonic muscle spasm

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Clonic muscle spasm

What the FDA AER plate says about Clonic muscle spasm

Signature read: 20 reports place Clonic muscle spasm in the lower third of FDA AER volume (#2159 of 2,481). Report volume is lower-third scale: 20 named reports in the openFDA extract. 2 of 20 reports were death-coded (10.0% of named reports, not a population mortality rate). Nearest volume peer: Agalactia (±0 reports). Lead species Dog (16). Lead co-reported drug Spinosad (3).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 16

Cat 3

Human 1

Breeds Most Affected

Retriever - Labrador 4

Spaniel - King Charles Cavalier 2

Domestic Longhair 1

Griffon (unspecified) 1

Chihuahua 1

Pinscher - Miniature 1

Domestic Mediumhair 1

Unknown 1

Collie - Border 1

Crossbred Canine/dog 1

Associated Drugs

Spinosad 3

Alfaxalone 3

Milbemycin Oxime + Spinosad 2

Moxidectin 2

Dexamethasone 2

Afoxolaner 2

Ivermectin + Pyrantel As Pamoate Salt 2

Isoflurane 2

Flea Product (Unknown) 1

Vaccines (Unknown) 1

Selamectin 1

Enrofloxacin 1

Imidocarb Dipropionate Inj Sol 1

Rabies Vaccine 1

Dhppl Vaccine 1

Bordetella Vaccine 1

Butorphanol 1

Acepromazine 1

Sarolaner 1

Ivermectin 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Clonic muscle spasm (#2159 of 2,481 by report volume); death-coded 10.0%. PlainBreed reaction plate · report volume stamp 20 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →