Reaction profile

The FDA adverse-event record for chordae tendonae rupture

13 FDA adverse-event reports reference chordae tendonae rupture (VeDDRA 2428). See the species, breeds, and drugs most associated with it below.

13
reports citing this reaction
61.5%
death-coded share
Dog
most-affected species
Pimobendan
most-associated drug
Verify with FDA CVM →
13
Total Reports
8
Deaths
61.5%
Death Rate

Species Most Affected

Dog 13

Breeds Most Affected

Crossbred Canine/dog 2
Maltese 2
Shih Tzu 2
Spaniel - Cocker American 2
Spaniel - King Charles Cavalier 2
Dachshund (unspecified) 1
Terrier (unspecified) 1
Chihuahua 1

Associated Drugs

Pimobendan 6
Furosemide 2
Moxidectin 2
Hydrocodone 1
Oclacitinib Maleate 1
Anti-Il31 Mab Mcs Lot #1283563 1
Pyrantel Pamoate;Sarolaner 1
Bravecto 1
Lactulose 1
Subcutaneous Fluids 1
Fluralaner 13.64% 12-Week Chew 1
Fipronil + S-Methoprene 1
Cyclosporin Ointment 1
Vetmedin Pimobendan Chewable 1.25 Mg Np 1
Unknown Furosemide 1
Metronidazole 1
Milbemycin Oxime + Praziquantel 1
Vetmedin Pimobendan Chewable 2.5 Mg Np 1
Fipronil 10%/S Methoprene 9% Spot On 1
Bedinvetmab 1

Chordae tendonae rupture Reaction Insights

13 reports name Chordae tendonae rupture; 8 recorded a death outcome (61.5% of reported events, not a population-level mortality rate). VeDDRA code: 2428.

By species: Dog (13 reports). By breed: Crossbred Canine/dog (2), Maltese (2), Shih Tzu (2).

Most co-reported drugs: Pimobendan (6 reports), Furosemide (2 reports), Moxidectin (2 reports), Hydrocodone (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.