Reaction profile

The FDA adverse-event record for chordae tendonae rupture

14 FDA reports name chordae tendonae rupture, a lower-volume reaction in the CVM extract (VeDDRA 2428). Plate stamps and neighbourhood peers follow.

#2322 of 2,481
by report volume (all reactions)
14
reports citing this reaction
64.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Chordae tendonae rupture has 14 reports now versus 14 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Chordae tendonae rupture changes

FDA AER · VeDDRA plate

Code 2428 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 14 reports
  • DEATH-HOT 64.3%
  • BOTTOM-DECILE #2322/2481
  • PHOTO-FINISH Addisonian crisis
  • SPECIES-DOG Dog · 14
  • DRUG-LEAD Pimobendan · 6
  • DESK-WIDE 8 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Addisonian crisis (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Chordae tendonae rupture

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Addisonian crisis · near14Application site puru… · near14Bullous disorder NOS · near14Chapped skin · near14Chordae tendonae rupt… · thi…14Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Chordae tendonae rupture

Chordae tendonae rupture: high death-coded share in the FDA AER plate

Signature read: 14 reports place Chordae tendonae rupture in the lower third of FDA AER volume (#2322 of 2,481). Report volume is lower-third scale: 14 named reports in the openFDA extract. Death-coded share is upper-third: 9 of 14 reports (64.3% of named reports). Nearest volume peer: Addisonian crisis (±0 reports). Lead species Dog (14). Lead co-reported drug Pimobendan (6).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 14

Breeds Most Affected

Crossbred Canine/dog 2
Maltese 2
Shih Tzu 2
Spaniel - Cocker American 2
Spaniel - King Charles Cavalier 2
Chihuahua 2
Dachshund (unspecified) 1
Terrier (unspecified) 1

Associated Drugs

Pimobendan 6
Furosemide 2
Moxidectin 2
Bedinvetmab 2
Hydrocodone 1
Oclacitinib Maleate 1
Anti-Il31 Mab Mcs Lot #1283563 1
Pyrantel Pamoate;Sarolaner 1
Fluralaner 13.64% 12-Week Chew 1
Bravecto 1
Lactulose 1
Subcutaneous Fluids 1
Fipronil + S-Methoprene 1
Cyclosporin Ointment 1
Vetmedin Pimobendan Chewable 1.25 Mg Np 1
Unknown Furosemide 1
Metronidazole 1
Milbemycin Oxime + Praziquantel 1
Vetmedin Pimobendan Chewable 2.5 Mg Np 1
Fipronil 10%/S Methoprene 9% Spot On 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Chordae tendonae rupture (#2322 of 2,481 by report volume); death-coded 64.3%. PlainBreed reaction plate · report volume stamp 14 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →