Reaction profile

The FDA adverse-event record for cerebrospinal fluid abnormal

22 FDA adverse-event reports reference cerebrospinal fluid abnormal (VeDDRA 99239). See the species, breeds, and drugs most associated with it below.

22
reports citing this reaction
27.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
22
Total Reports
6
Deaths
27.3%
Death Rate

Species Most Affected

Dog 19
Turtle 2
Cat 1

Breeds Most Affected

Unknown 2
Retriever - Labrador 2
Terrier - Silky 1
Crossbred Canine/dog 1
Retriever - Golden 1
Pug 1
Shepherd Dog - Australian 1
Collie - Border 1
Dachshund (unspecified) 1
Domestic Shorthair 1

Associated Drugs

Milbemycin Oxime + Spinosad 6
Spinosad 3
Prednisone 3
Tramadol 3
Propofol 2
Maropitant Citrate 2
Phenobarbital 2
Bordetella Bronchiseptica, Strain 78-9159, Kb 2
Mycophenolate 2
Doxycycline 2
Carprofen 2
Recombinant E. Coli Ecl19; Recombinant E. Coli Bl21 2
Pyrantel Pamoate 1
Cyclosporine 1
Rabies Vaccine 1
Distemper Vaccine 1
Bordetella Vaccine 1
Gentamicin Sulfate + Betamethasone 1
Anesthetic (Unknown) 1
Cefovecin 1

CEREBROSPINAL FLUID ABNORMAL Reaction Insights

22 reports name CEREBROSPINAL FLUID ABNORMAL; 6 recorded a death outcome (27.3% of reported events, not a population-level mortality rate). VeDDRA code: 99239.

By species: Dog (19 reports), Turtle (2 reports), Cat (1 reports). By breed: Unknown (2), Retriever - Labrador (2), Terrier - Silky (1).

Most co-reported drugs: Milbemycin Oxime + Spinosad (6 reports), Spinosad (3 reports), Prednisone (3 reports), Tramadol (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.