Reaction profile

The FDA adverse-event record for cerebrospinal fluid abnormal

22 FDA reports name cerebrospinal fluid abnormal, a lower-volume reaction in the CVM extract (VeDDRA 99239). Plate stamps and neighbourhood peers follow.

#2124 of 2,481
by report volume (all reactions)
22
reports citing this reaction
27.3%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. CEREBROSPINAL FLUID ABNORMAL has 22 reports now versus 22 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

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FDA AER · VeDDRA plate

Code 99239 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 22 reports
  • DEATH-HOT 27.3%
  • LOWER-Q #2124/2481
  • PHOTO-FINISH Adenocarcinoma NOS
  • SPECIES-DOG Dog · 19
  • DRUG-LEAD Milbemycin Oxime… · 6
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Adenocarcinoma NOS (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around CEREBROSPINAL FLUID ABNORMAL

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Adenocarcinoma NOS · near22Bolus, Abnormal · near22Bone marrow aplasia · near22CEREBROSPINAL FLUID A… · thi…22Founder · near22Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around CEREBROSPINAL FLUID ABNORMAL

CEREBROSPINAL FLUID ABNORMAL: high death-coded share in the FDA AER plate

Signature read: 22 reports place CEREBROSPINAL FLUID ABNORMAL in the lower third of FDA AER volume (#2124 of 2,481). Report volume is lower-third scale: 22 named reports in the openFDA extract. Death-coded share is upper-third: 6 of 22 reports (27.3% of named reports). Nearest volume peer: Adenocarcinoma NOS (±0 reports). Lead species Dog (19). Lead co-reported drug Milbemycin Oxime + Spinosad (6).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 19
Turtle 2
Cat 1

Breeds Most Affected

Unknown 2
Retriever - Labrador 2
Terrier - Silky 1
Retriever - Golden 1
Crossbred Canine/dog 1
Pug 1
Shepherd Dog - Australian 1
Dachshund (unspecified) 1
Collie - Border 1
Domestic Shorthair 1

Associated Drugs

Milbemycin Oxime + Spinosad 6
Spinosad 3
Prednisone 3
Tramadol 3
Propofol 2
Maropitant Citrate 2
Phenobarbital 2
Bordetella Bronchiseptica, Strain 78-9159, Kb 2
Mycophenolate 2
Doxycycline 2
Carprofen 2
Recombinant E. Coli Ecl19; Recombinant E. Coli Bl21 2
Pyrantel Pamoate 1
Cyclosporine 1
Rabies Vaccine 1
Distemper Vaccine 1
Bordetella Vaccine 1
Gentamicin Sulfate + Betamethasone 1
Cefovecin 1
Buprenorphine Hcl 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for CEREBROSPINAL FLUID ABNORMAL (#2124 of 2,481 by report volume); death-coded 27.3%. PlainBreed reaction plate · report volume stamp 22 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →