Reaction profile

The FDA adverse-event record for cardiac tamponade

24 FDA adverse-event reports reference cardiac tamponade (VeDDRA 236). See the species, breeds, and drugs most associated with it below.

24
reports citing this reaction
83.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
24
Total Reports
20
Deaths
83.3%
Death Rate

Species Most Affected

Dog 22
Cattle 1
Snake 1

Breeds Most Affected

Siberian Husky 3
Retriever - Golden 3
Shepherd Dog - German 2
Shepherd Dog - Australian 2
Cattle (other) 1
Terrier - Bull - American Pit 1
Greyhound 1
Crossbred Canine/dog 1
Akita 1
Collie - Border 1

Associated Drugs

Milbemycin Oxime + Spinosad 5
Carprofen 2
Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St 2
Enrofloxacin 2
Spinosad 2
Moxidectin 2
Ivermectin + Pyrantel As Pamoate Salt 2
Maropitant Citrate 2
Pyrantel Pamoate;Sarolaner 2
Monensin Sodium 1
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 1
Doxycycline 1
Rabies Vaccine 1
Distemper Vaccine 1
Bordetella Vaccine 1
Canine Influenza Virus H3N8, Kv 1
Canine Influenza Virus H3N2, Kv 1
Cefazolin 1
Afoxolaner 68 Mg Chewable Tablets 1

Cardiac tamponade Reaction Insights

24 reports name Cardiac tamponade; 20 recorded a death outcome (83.3% of reported events, not a population-level mortality rate). VeDDRA code: 236.

By species: Dog (22 reports), Cattle (1 reports), Snake (1 reports). By breed: Siberian Husky (3), Retriever - Golden (3), Shepherd Dog - German (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (5 reports), Carprofen (2 reports), Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St (2 reports), Enrofloxacin (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.