Reaction profile

The FDA adverse-event record for carbon dioxide high, blood

37 FDA reports name carbon dioxide high, blood, a lower-volume reaction in the CVM extract (VeDDRA 99229). Plate stamps and neighbourhood peers follow.

#1888 of 2,481
by report volume (all reactions)
37
reports citing this reaction
37.8%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. CARBON DIOXIDE HIGH, BLOOD has 37 reports now versus 36 in that prior snapshot: 1 more (2.8%).

Report change
+1
Death-coded reports
+0
Death-coded share
−1.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to CARBON DIOXIDE HIGH, BLOOD changes

FDA AER · VeDDRA plate

Code 99229 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 37 reports
  • DEATH-HOT 37.8%
  • LOWER-Q #1888/2481
  • PHOTO-FINISH Blistering of mouth
  • SPECIES-DOG Dog · 21
  • DRUG-LEAD Sevoflurane · 5
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Blistering of mouth (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around CARBON DIOXIDE HIGH, BLOOD

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Blistering of mouth · near37CARBON DIOXIDE HIGH,… · this…37Cartilage degeneration · near37Cleft palate · near37Depigmentation of nas… · near37Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around CARBON DIOXIDE HIGH, BLOOD

CARBON DIOXIDE HIGH, BLOOD: high death-coded share in the FDA AER plate

Signature read: CARBON DIOXIDE HIGH, BLOOD's 37.8% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 37 named reports in the openFDA extract. Death-coded share is upper-third: 14 of 37 reports (37.8% of named reports). Nearest volume peer: Blistering of mouth (±0 reports). Lead species Dog (21). Lead co-reported drug Sevoflurane (5).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 21
Cat 11
Horse 2
Alpaca 2
Mouse 1

Breeds Most Affected

Domestic (unspecified) 3
Terrier - Yorkshire 3
Domestic Shorthair 3
Boxer (German Boxer) 3
Spaniel - Cocker American 2
Beagle 2
Greyhound 2
Alpaca 2
Mouse (unknown) 1
Dog (unknown) 1

Associated Drugs

Sevoflurane 5
Propofol 5
Meloxicam 4
Isoflurane 3
Pimobendan 2
Butorphanol 2
Ivermectin + Pyrantel As Pamoate Salt 2
Buprenorphine 2
Sirolimus 2
Dexmedetomidine Hydrochloride 1
Cefovecin Sodium 1
Spinosad 1
Melarsomine Dihydrochloride 1
N-Butylscopolammonium 1
Glycosaminoglycan Polysulfate 1
Rabies Non Adjuvanted Vaccine 1
Cefovecin 1
Acepromazine Maleate 1
Morphine 1
Ampicillin 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for CARBON DIOXIDE HIGH, BLOOD (#1888 of 2,481 by report volume); death-coded 37.8%. PlainBreed reaction plate · death-coded share stamp 37.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →