Reaction profile

The FDA adverse-event record for buccal ulceration

25 FDA adverse-event reports reference buccal ulceration (VeDDRA 298). See the species, breeds, and drugs most associated with it below.

25
reports citing this reaction
16.0%
death-coded share
Dog
most-affected species
Grapiprant
most-associated drug
Verify with FDA CVM →
25
Total Reports
4
Deaths
16.0%
Death Rate

Species Most Affected

Dog 18
Horse 4
Cat 3

Breeds Most Affected

Domestic Shorthair 3
Horse (unknown) 2
Retriever (unspecified) 1
Retriever - Labrador 1
Setter - English 1
Bichon Frise 1
Percheron 1
Boxer (German Boxer) 1
Collie - Border 1
Terrier - Boston 1

Associated Drugs

Grapiprant 4
Firocoxib 3
Tramadol 3
Carprofen 3
Rabies Vaccine 3
Prednisone 2
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 2
Meloxicam 2
Cefovecin 2
Robenacoxib 2
Spinosad 1
Isoflupredone Acetate; Neomycin Sulfate; Tetracaine Hydrochloride 1
Milbemycin Oxime + Spinosad 1
Hexetidine 1
Omeprazole 37% Oral Paste 1
Recombinant Human Insulin 1
Cephalexin 1
Propofol 1
Isoflurane 1
Clindamycin 1

Buccal ulceration Reaction Insights

25 reports name Buccal ulceration; 4 recorded a death outcome (16.0% of reported events, not a population-level mortality rate). VeDDRA code: 298.

By species: Dog (18 reports), Horse (4 reports), Cat (3 reports). By breed: Domestic Shorthair (3), Horse (unknown) (2), Retriever (unspecified) (1).

Most co-reported drugs: Grapiprant (4 reports), Firocoxib (3 reports), Tramadol (3 reports), Carprofen (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.