Reaction profile

The FDA adverse-event record for brain damage nos

48 FDA reports name brain damage nos, a lower-volume reaction in the CVM extract (VeDDRA 629). Plate stamps and neighbourhood peers follow.

#1755 of 2,481
by report volume (all reactions)
48
reports citing this reaction
64.6%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Brain damage NOS has 48 reports now versus 47 in that prior snapshot: 1 more (2.1%).

Report change
+1
Death-coded reports
+1
Death-coded share
+0.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Brain damage NOS changes

FDA AER · VeDDRA plate

Code 629 VOL-TRACE

VOL-TRACE · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 48 reports
  • DEATH-HOT 64.6%
  • MID-PACK #1755/2481
  • PHOTO-FINISH Abnormal echocardiogr…
  • SPECIES-DOG Dog · 39
  • DRUG-LEAD Pyrantel Pamoate;… · 9
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal echocardiogram (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Brain damage NOS

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal echocardiogr… · near48Application site absc… · near48Brain damage NOS · this reac…48Brain tumour · near48Infarction · near48Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Brain damage NOS

Brain damage NOS: high death-coded share in the FDA AER plate

Signature read: Brain damage NOS's 64.6% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 48 named reports in the openFDA extract. Death-coded share is upper-third: 31 of 48 reports (64.6% of named reports). Nearest volume peer: Abnormal echocardiogram (±0 reports). Lead species Dog (39). Lead co-reported drug Pyrantel Pamoate;Sarolaner (9).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 39
Cat 5
Horse 2
Pig 1
Monkey 1

Breeds Most Affected

Chihuahua 6
Domestic Shorthair 5
Terrier - Yorkshire 4
Terrier - Jack Russell 3
Quarter Horse 2
Dog (unknown) 2
Schnauzer - Miniature 2
Shepherd Dog - Australian 2
Unknown 2
Mastiff (unspecified) 2

Associated Drugs

Pyrantel Pamoate;Sarolaner 9
Maropitant Citrate 6
Isoflurane 5
Anti-Il31 Mab Mcs Lot #1283563 4
Midazolam Hydrochloride 3
Carprofen 3
Selamectin 3
Atipamezole Hydrochloride 3
Milbemycin Oxime + Spinosad 3
Moxidectin 3
Fluralaner 13.64% 12-Week Chew 3
Buprenorphine Hcl 2
Anesthetic 2
Dexmedetomidine Hydrochloride 2
Phenylpropanolamine 2
Sarolaner 2
Ketamine 2
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 2
Bupivacaine 2
Ketamine Hydrochloride 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Brain damage NOS (#1755 of 2,481 by report volume); death-coded 64.6%. PlainBreed reaction plate · death-coded share stamp 64.6% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →