Reaction profile

The FDA adverse-event record for bone marrow suppression

24 FDA adverse-event reports reference bone marrow suppression (VeDDRA 150). See the species, breeds, and drugs most associated with it below.

24
reports citing this reaction
41.7%
death-coded share
Dog
most-affected species
Cefovecin
most-associated drug
Verify with FDA CVM →
24
Total Reports
10
Deaths
41.7%
Death Rate

Species Most Affected

Dog 16
Cat 6
Alpaca 1
Horse 1

Breeds Most Affected

Domestic Shorthair 5
Retriever - Labrador 3
Dachshund (unspecified) 1
Kuvasz 1
Terrier - Scottish 1
Crossbred Canine/dog 1
Alpaca 1
Great Pyrenees 1
Alaskan Malamute 1
Dog (unknown) 1

Associated Drugs

Cefovecin 3
Oclacitinib Maleate 3
Imidacloprid + Moxidectin 2
Moxidectin 2
Doxycycline 2
Orbafloxacin 1
Buprenorphine 1
Clindamycin 1
Steroid 1
Milbemycin Oxime + Spinosad 1
Fluralaner Chew Tablets 1
Prednisolone; Trimeprazine Tartrate 1
Maropitant Citrate 1
Melphalan 1
Albendazole 1
Ampicillin Sodium & Sulbactam Sodium 1
Marbofloxacin 1
Caninie Vaccine 1
Phenobarbital 1
Zonisamide 1

Bone marrow suppression Reaction Insights

24 reports name Bone marrow suppression; 10 recorded a death outcome (41.7% of reported events, not a population-level mortality rate). VeDDRA code: 150.

By species: Dog (16 reports), Cat (6 reports), Alpaca (1 reports). By breed: Domestic Shorthair (5), Retriever - Labrador (3), Dachshund (unspecified) (1).

Most co-reported drugs: Cefovecin (3 reports), Oclacitinib Maleate (3 reports), Imidacloprid + Moxidectin (2 reports), Moxidectin (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.