Reaction profile

The FDA adverse-event record for bilirubin(indirect) high, bld

12 FDA reports name bilirubin(indirect) high, bld, a lower-volume reaction in the CVM extract (VeDDRA 99197). Plate stamps and neighbourhood peers follow.

#2378 of 2,481
by report volume (all reactions)
12
reports citing this reaction
66.7%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. BILIRUBIN(INDIRECT) HIGH, BLD has 12 reports now versus 12 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to BILIRUBIN(INDIRECT) HIGH, BLD changes

FDA AER · VeDDRA plate

Code 99197 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 12 reports
  • DEATH-HOT 66.7%
  • BOTTOM-DECILE #2378/2481
  • PHOTO-FINISH Agitated state of mind
  • SPECIES-DOG Dog · 11
  • DRUG-LEAD Carprofen · 3
  • DESK-WIDE 10 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Agitated state of mind (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around BILIRUBIN HIGH, BLD

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Agitated state of mind · near12Airsacculitis · near12Anal prolapse · near12Anal sac adenocarcioma · near12BILIRUBIN(INDIRECT) H… · thi…12Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around BILIRUBIN(INDIRECT) HIGH, BLD

BILIRUBIN(INDIRECT) HIGH, BLD: high death-coded share in the FDA AER plate

Signature read: 12 reports place BILIRUBIN(INDIRECT) HIGH, BLD in the lower third of FDA AER volume (#2378 of 2,481). Report volume is lower-third scale: 12 named reports in the openFDA extract. Death-coded share is upper-third: 8 of 12 reports (66.7% of named reports). Nearest volume peer: Agitated state of mind (±0 reports). Lead species Dog (11). Lead co-reported drug Carprofen (3).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 11
Cat 1

Breeds Most Affected

Retriever - Labrador 3
Sheepdog - Shetland 1
Newfoundland 1
Schnauzer - Miniature 1
Bulldog - French 1
Pekingese 1
Terrier - Scottish 1
Domestic Shorthair 1
Terrier - Yorkshire 1
Schnauzer (unspecified) 1

Associated Drugs

Carprofen 3
Fluralaner Chew Tablets 3
Afoxolaner 2
Firocoxib 1
Clotrimazole, Gentamicin Sulfate, Mometasone Furoate Monohydrate 1
Desoxycorticosterone Pivalate 1
Probiotic 1
Amitriptylline 1
Diphenhydramine 1
Prednisone 1
Genta/Momet/Clotrim Ear Oint 1
Insulin Injectable Vial 1
Maropitant 1
Milbemycin Oxime 1
Cefovecin 1
Milbemycin Oxime + Spinosad 1
Ivermectin + Pyrantel As Pamoate Salt 1
Deracoxib 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for BILIRUBIN(INDIRECT) HIGH, BLD (#2378 of 2,481 by report volume); death-coded 66.7%. PlainBreed reaction plate · report volume stamp 12 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →