Reaction profile

The FDA adverse-event record for application site paraesthesia

22 FDA adverse-event reports reference application site paraesthesia (VeDDRA 2112). See the species, breeds, and drugs most associated with it below.

22
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
22
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Dog 11
Cat 7
Human 3
Cattle 1

Breeds Most Affected

Domestic Shorthair 4
Crossbred Canine/dog 3
Unknown 3
Shih Tzu 2
Bichon Frise 1
Cattle (unknown) 1
Siamese 1
Chihuahua 1
Maine Coon 1
Oriental 1

Associated Drugs

Selamectin 3
Selamectin;Sarolaner 3
Oclacitinib Maleate 3
Milbemycin Oxime 3
Fluralaner Spot-On Solution 2
Imidacloprid + Moxidectin 2
Vectra 3D For Dogs And Puppies 21-55 Lbs 2
Dinotefuran + Pyriproxyfen + Permethrin 2
Ivermectin + Pyrantel As Pamoate Salt 1
Fipronil 9.8%/S-Methoprene 8.8%/Cyphenothrin 5.2% Squeeze-On 1
Ivermectin 0.5% Pour-On Topical Solution 1
Nystatin/Neomycin Sulfate/Thiostrepton/Triamcinolone Acetonide 1
Dexamethasone 1
Steroid 1
Milbemycin Oxime + Praziquantel 1
Cyphenothrin + Fipronil 1
Copper Naphthenate 1
Fluralaner/Moxidectin Spot-On 1
Vectra 3D For Dogs And Puppies 11 - 20 Lbs 1
Grapiprant 1

Application site paraesthesia Reaction Insights

22 reports name Application site paraesthesia; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 2112.

By species: Dog (11 reports), Cat (7 reports), Human (3 reports). By breed: Domestic Shorthair (4), Crossbred Canine/dog (3), Unknown (3).

Most co-reported drugs: Selamectin (3 reports), Selamectin;Sarolaner (3 reports), Oclacitinib Maleate (3 reports), Milbemycin Oxime (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.