Reaction profile

The FDA adverse-event record for ammonia increased, blood

Name: AMMONIA INCREASED, BLOOD - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

16 FDA reports name ammonia increased, blood, a lower-volume reaction in the CVM extract (VeDDRA 99186). Plate stamps and neighbourhood peers follow.

#2258 of 2,481
by report volume (all reactions): 16
reports citing this reaction: 50.0%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. AMMONIA INCREASED, BLOOD has 16 reports now versus 16 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to AMMONIA INCREASED, BLOOD changes

FDA AER · VeDDRA plate

Code 99186 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 16 reports
DEATH-HOT 50.0%
BOTTOM-DECILE #2258/2481
PHOTO-FINISH Abdominal transudate
SPECIES-DOG Dog · 14
DRUG-LEAD Carprofen · 4
DESK-WIDE 13 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Abdominal transudate (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around AMMONIA INCREASED, BLOOD

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around AMMONIA INCREASED, BLOOD

AMMONIA INCREASED, BLOOD: high death-coded share in the FDA AER plate

Signature read: 16 reports place AMMONIA INCREASED, BLOOD in the lower third of FDA AER volume (#2258 of 2,481). Report volume is lower-third scale: 16 named reports in the openFDA extract. Death-coded share is upper-third: 8 of 16 reports (50.0% of named reports). Nearest volume peer: Abdominal transudate (±0 reports). Lead species Dog (14). Lead co-reported drug Carprofen (4).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 14

Cat 1

Horse 1

Breeds Most Affected

Retriever - Labrador 4

Chihuahua 1

Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1

Domestic (unspecified) 1

Shar Pei 1

Warmblood (unspecified) 1

Collie (unspecified) 1

Akita 1

Saint Bernard Dog 1

Mountain Dog - Bernese 1

Associated Drugs

Carprofen 4

Metronidazole 3

Lotilaner 3

Toceranib Phosphate 2

Buprenorphine 2

Prednisolone 2

Enrofloxacin 2

Aphanizomenon Flos-Aquae 2

Milbemycin Oxime 2

Cefovecin Sodium 1

Melarsomine Dihydrochloride 1

Cefpodoxime Proxetil 1

Selamectin 1

Ampicillin Sodium & Sulbactam Sodium 1

Lactulose 1

S-Adenosylmethionine 1

Acetylcysteine Solution 1

Famotidine 1

Diphenhydramine Hcl 1

Sucralfate 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for AMMONIA INCREASED, BLOOD (#2258 of 2,481 by report volume); death-coded 50.0%. PlainBreed reaction plate · report volume stamp 16 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →