Reaction profile

The FDA adverse-event record for ammonia increased, blood

16 FDA adverse-event reports reference ammonia increased, blood (VeDDRA 99186). See the species, breeds, and drugs most associated with it below.

16
reports citing this reaction
50.0%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
16
Total Reports
8
Deaths
50.0%
Death Rate

Species Most Affected

Dog 14
Cat 1
Horse 1

Breeds Most Affected

Retriever - Labrador 4
Chihuahua 1
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1
Domestic (unspecified) 1
Shar Pei 1
Warmblood (unspecified) 1
Collie (unspecified) 1
Akita 1
Saint Bernard Dog 1
Mountain Dog - Bernese 1

Associated Drugs

Carprofen 4
Metronidazole 3
Lotilaner 3
Toceranib Phosphate 2
Buprenorphine 2
Prednisolone 2
Enrofloxacin 2
Aphanizomenon Flos-Aquae 2
Milbemycin Oxime 2
Cefovecin Sodium 1
Melarsomine Dihydrochloride 1
Cefpodoxime Proxetil 1
Selamectin 1
Ampicillin Sodium & Sulbactam Sodium 1
Lactulose 1
S-Adenosylmethionine 1
Acetylcysteine Solution 1
Famotidine 1
Diphenhydramine Hcl 1
Sucralfate 1

AMMONIA INCREASED, BLOOD Reaction Insights

16 reports name AMMONIA INCREASED, BLOOD; 8 recorded a death outcome (50.0% of reported events, not a population-level mortality rate). VeDDRA code: 99186.

By species: Dog (14 reports), Cat (1 reports), Horse (1 reports). By breed: Retriever - Labrador (4), Chihuahua (1), Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) (1).

Most co-reported drugs: Carprofen (4 reports), Metronidazole (3 reports), Lotilaner (3 reports), Toceranib Phosphate (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.