Drug profile

The FDA adverse-event record for Xylitol

34 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Xylitol. See the species affected, top reactions, and outcomes below.

34
adverse-event reports
11.8%
death-coded share
Dog
most-reported species
18
Accidental exposure - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
34
Total Reports
4
Deaths Reported
11.8%
Death Rate

Active Ingredients

Xylitol

Administration Routes

OralUnknown

Species Affected

Dog 33
Unknown 1

Most Affected Breeds

Dog (unknown) 16
Retriever - Labrador 4
Shepherd Dog - German 2
Crossbred Canine/dog 2
Mixed (Dog) 1
Bichon Frise 1
Dachshund (unspecified) 1
Spitz - German Pomeranian 1
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1
Unknown 1

Most Reported Reactions

Accidental exposure 18
Hypoglycaemia 12
Vomiting 10
Seizure NOS 8
Liver failure 5
Lethargy (see also Central nervous system depression in 'Neurological') 4
Elevated liver enzymes 4
Product label issues 3
Collapse NOS (see also 'Cardio-vascular' and 'Neurological disorders') 3
Elevated alanine aminotransferase (ALT) 3
Hepatopathy 2
Death by euthanasia 2

Outcome Breakdown

Outcome Unknown
15 (48.4%)
Ongoing
8 (25.8%)
Recovered/Normal
4 (12.9%)
Euthanized
2 (6.5%)
Died
2 (6.5%)

Xylitol Adverse Event Insights

34 reports name Xylitol; 4 recorded a death outcome (11.8% of reported events, not a population-level mortality rate). Active ingredient: Xylitol. Administration routes: Oral, Unknown.

By species: Dog (33 reports), Unknown (1 reports). By breed: Dog (unknown) (16), Retriever - Labrador (4), Shepherd Dog - German (2).

Leading clinical signs: Accidental exposure (18), Hypoglycaemia (12), Vomiting (10), Seizure NOS (8). Outcome, 31 coded reports: Outcome Unknown leads at 48.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.