Drug profile

The FDA adverse-event record for Vitamin B12 Injection

17 FDA reports name Vitamin B12 Injection, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#1992 of 2,679
by report volume (all drugs)
17
adverse-event reports
35.3%
death-coded share
Cat
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Vitamin B12 Injection ranks #1937 of 2679 by total reports (17). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1937
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Vitamin B12 Injection has 17 reports now versus 16 in that prior snapshot: 1 more (6.3%).

Report change
+1
Death-coded reports
+0
Death-coded share
−2.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Vitamin B12 Injection changes

Signature read: Vitamin B12 Injection's 35.3% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
17
Total Reports
6
Deaths Reported
35.3%
Death-coded share of reports

Active Ingredients

Vitamin B12 Injection

Administration Routes

UnknownSubcutaneousParenteral

Species Affected

Cat 11
Dog 6

Most Affected Breeds

Domestic Shorthair 3
Retriever - Golden 3
Domestic Mediumhair 3
Bengal 2
Siamese 1
Maine Coon 1
Mountain Cur 1
Sheepdog - Shetland 1
Chihuahua 1
Domestic Longhair 1

Most Reported Reactions

Diarrhoea 4
Vomiting 4
Death by euthanasia 4
Not eating 3
Lethargy (see also Central nervous system depression in Neurological) 3
Panting 3
Fever 3
Anorexia 3
Hyperphosphataemia 2
Weight loss 2
Low thyroxine (T4) 2
Breathing difficulty 2

Outcome Breakdown

Ongoing
6 (35.3%)
Euthanized
4 (23.5%)
Recovered/Normal
3 (17.6%)
Died
2 (11.8%)
Recovered with Sequela
1 (5.9%)
Outcome Unknown
1 (5.9%)

Vitamin B12 Injection: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Vitamin B12 Injection (#1992 of 2,679 by report volume); death-coded 35.3%. PlainBreed drug row · death-coded share stamp 35.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →