Drug profile

The FDA adverse-event record for Vitamin B12 Injection

16 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Vitamin B12 Injection. See the species affected, top reactions, and outcomes below.

16
adverse-event reports
37.5%
death-coded share
Cat
most-reported species
4
Diarrhoea - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
16
Total Reports
6
Deaths Reported
37.5%
Death Rate

Active Ingredients

Vitamin B12 Injection

Administration Routes

UnknownSubcutaneousParenteral

Species Affected

Cat 10
Dog 6

Most Affected Breeds

Domestic Shorthair 3
Retriever - Golden 3
Domestic Mediumhair 3
Bengal 2
Siamese 1
Maine Coon 1
Mountain Cur 1
Sheepdog - Shetland 1
Chihuahua 1

Most Reported Reactions

Diarrhoea 4
Vomiting 4
Death by euthanasia 4
Not eating 3
Lethargy (see also Central nervous system depression in Neurological) 3
Panting 3
Fever 3
Anorexia 3
Hyperphosphataemia 2
Weight loss 2
Low thyroxine (T4) 2
Breathing difficulty 2

Outcome Breakdown

Ongoing
5 (31.3%)
Euthanized
4 (25.0%)
Recovered/Normal
3 (18.8%)
Died
2 (12.5%)
Recovered with Sequela
1 (6.3%)
Outcome Unknown
1 (6.3%)

Vitamin B12 Injection Adverse Event Insights

16 reports name Vitamin B12 Injection; 6 recorded a death outcome (37.5% of reported events, not a population-level mortality rate). Active ingredient: Vitamin B12 Injection. Administration routes: Unknown, Subcutaneous, Parenteral.

By species: Cat (10 reports), Dog (6 reports). By breed: Domestic Shorthair (3), Retriever - Golden (3), Domestic Mediumhair (3).

Leading clinical signs: Diarrhoea (4), Vomiting (4), Death by euthanasia (4), Not eating (3). Outcome, 16 coded reports: Ongoing leads at 31.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.