Drug profile

The FDA adverse-event record for Unspecified Flea Spray

15 FDA reports name Unspecified Flea Spray, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2129 of 2,679
by report volume (all drugs)
15
adverse-event reports
13.3%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Unspecified Flea Spray ranks #2072 of 2679 by total reports (15). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#2072
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Unspecified Flea Spray has 15 reports now versus 15 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Unspecified Flea Spray changes

Signature read: 15 reports place Unspecified Flea Spray in the lower third of FDA AER volume (#2129 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
15
Total Reports
2
Deaths Reported
13.3%
Death-coded share of reports

Active Ingredients

Unspecified Flea Spray

Administration Routes

TopicalUnknownOralOther

Species Affected

Dog 11
Cat 4

Most Affected Breeds

Domestic Shorthair 3
Shepherd Dog - Australian 3
Spitz - German Pomeranian 1
Maltese 1
Retriever - Golden 1
Weimaraner 1
Siberian Husky 1
Cat (unknown) 1
Boxer (German Boxer) 1
Pit Bull 1

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 10
Death 2
Vomiting 1
Papule 1
Pruritus 1
Skin sore 1
Drug dose administration interval too short 1
Itching 1
Reddening of the skin 1
Rash 1
Scratching 1
Coma 1

Outcome Breakdown

Outcome Unknown
13 (86.7%)
Died
2 (13.3%)

Unspecified Flea Spray: lower report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Unspecified Flea Spray (#2129 of 2,679 by report volume); death-coded 13.3%. PlainBreed drug row · report volume stamp 15 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →