Drug profile

The FDA adverse-event record for Unspecified Fipronil

Name: Unspecified Fipronil - FDA Animal Adverse Event Reports
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

22 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Unspecified Fipronil. See the species affected, top reactions, and outcomes below.

22
adverse-event reports: 0.0%
death-coded share: Dog
most-reported species: 13
Lack of efficacy (ectoparasite) - flea - top reaction

Compiled by PlainBreed Editorial, Pet Health Editorial Team

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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

0.0%

Death Rate

Active Ingredients

Unspecified Fipronil

Administration Routes

Topical

Species Affected

Dog 12

Cat 10

Most Affected Breeds

Domestic Shorthair 6

Catahoula Leopard Dog 4

Retriever - Labrador 2

Schnauzer - Giant 1

Terrier (unspecified) 1

Domestic Longhair 1

Siamese 1

Siberian Husky 1

Beagle 1

Brittany 1

Most Reported Reactions

Lack of efficacy (ectoparasite) - flea 13

Panting 3

Hyperactivity 2

Vocalisation 2

Trembling 2

Warm feeling to the touch 2

Lack of efficacy - NOS 2

Heavy breathing 1

Lethargy (see also Central nervous system depression in 'Neurological') 1

Shaking 1

Lack of awareness 1

Seizure NOS 1

Outcome Breakdown

Outcome Unknown

14 (63.6%)

Recovered/Normal

6 (27.3%)

Ongoing

2 (9.1%)

Unspecified Fipronil Adverse Event Insights

22 reports name Unspecified Fipronil; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). Active ingredient: Unspecified Fipronil. Administration route: Topical.

By species: Dog (12 reports), Cat (10 reports). By breed: Domestic Shorthair (6), Catahoula Leopard Dog (4), Retriever - Labrador (2).

Leading clinical signs: Lack of efficacy (ectoparasite) - flea (13), Panting (3), Hyperactivity (2), Vocalisation (2). Outcome, 22 coded reports: Outcome Unknown leads at 63.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.