Drug profile

The FDA adverse-event record for Unknown Anesthetics

48 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Unknown Anesthetics. Species, reactions, and outcomes follow.

#1153 of 2,679
by report volume (all drugs)
48
adverse-event reports
18.8%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Unknown Anesthetics ranks #1140 of 2679 by total reports (48). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1140
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Unknown Anesthetics has 48 reports now versus 48 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Unknown Anesthetics changes

Signature read: Unknown Anesthetics's 18.8% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
48
Total Reports
9
Deaths Reported
18.8%
Death-coded share of reports

Active Ingredients

Unknown Anesthetics

Administration Routes

Unknown

Species Affected

Dog 29
Cat 19

Most Affected Breeds

Domestic Shorthair 14
Maine Coon 2
Boxer (German Boxer) 2
Retriever - Chesapeake Bay 2
Crossbred Canine/dog 2
Retriever - Labrador 2
Terrier - Jack Russell 2
Chihuahua 1
Domestic Longhair 1
Cat (unknown) 1

Most Reported Reactions

Vomiting 6
Death by euthanasia 6
Anorexia 6
Elevated blood urea nitrogen (BUN) 5
Other abnormal test result NOS 5
Diarrhoea 5
Lethargy (see also Central nervous system depression in 'Neurological') 5
Weight loss 4
Lack of efficacy - NOS 4
Seizure NOS 3
Death 3
Elevated creatinine 3

Outcome Breakdown

Outcome Unknown
21 (43.8%)
Ongoing
10 (20.8%)
Recovered/Normal
8 (16.7%)
Euthanized
5 (10.4%)
Died
4 (8.3%)

Unknown Anesthetics: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Unknown Anesthetics (#1153 of 2,679 by report volume); death-coded 18.8%. PlainBreed drug row · death-coded share stamp 18.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →