Drug profile

The FDA adverse-event record for Unasyn

29 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Unasyn. See the species affected, top reactions, and outcomes below.

29
adverse-event reports
62.1%
death-coded share
Dog
most-reported species
12
Death by euthanasia - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
29
Total Reports
18
Deaths Reported
62.1%
Death Rate

Active Ingredients

Unasyn

Administration Routes

UnknownIntravenous

Species Affected

Dog 24
Cat 5

Most Affected Breeds

Retriever - Labrador 4
Domestic Longhair 2
Mastiff 2
Bulldog - French 2
Domestic Shorthair 2
Retriever - Golden 2
Crossbred Canine/dog 2
Terrier - Bull - American Pit 1
Pointing Dog - German Short-haired 1
Borzoi 1

Most Reported Reactions

Death by euthanasia 12
Abnormal radiograph finding 8
Lethargy (see also Central nervous system depression in Neurological) 8
Anorexia 7
Leucocytosis NOS 6
Death 6
Vomiting 6
Neutrophilia 6
Diarrhoea 5
Weight loss 5
Fever 5
Other abnormal test result NOS 5

Outcome Breakdown

Euthanized
12 (41.4%)
Ongoing
6 (20.7%)
Died
6 (20.7%)
Recovered/Normal
3 (10.3%)
Outcome Unknown
2 (6.9%)

Unasyn Adverse Event Insights

29 reports name Unasyn; 18 recorded a death outcome (62.1% of reported events, not a population-level mortality rate). Active ingredient: Unasyn. Administration routes: Unknown, Intravenous.

By species: Dog (24 reports), Cat (5 reports). By breed: Retriever - Labrador (4), Domestic Longhair (2), Mastiff (2).

Leading clinical signs: Death by euthanasia (12), Abnormal radiograph finding (8), Lethargy (see also Central nervous system depression in Neurological) (8), Anorexia (7). Outcome, 29 coded reports: Euthanized leads at 41.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.