Drug profile

The FDA adverse-event record for Trenbolone Acetate + Estradiol

19 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Trenbolone Acetate + Estradiol. See the species affected, top reactions, and outcomes below.

19
adverse-event reports
84.2%
death-coded share
Cattle
most-reported species
15
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
19
Total Reports
16
Deaths Reported
84.2%
Death Rate

Active Ingredients

Trenbolone Acetate + Estradiol

Administration Routes

UnknownTopicalOtherParenteralSubcutaneous

Species Affected

Cattle 19

Most Affected Breeds

Cattle (unknown) 10
Cattle (other) 4
Crossbred Bovine/Cattle 3
Holstein-Friesian also known as Holstein 1
Aberdeen Angus 1

Most Reported Reactions

Death 15
Digestive tract disorder NOS 8
Respiratory tract disorder NOS 7
Bloated 5
Liver abscess 5
Pneumonia 4
Respiratory signs 4
Necropsy performed 4
Found dead 4
Lack of efficacy - NOS 3
Lung oedema 3
Lethargy (see also Central nervous system depression in 'Neurological') 2

Outcome Breakdown

Died
16 (51.6%)
Outcome Unknown
13 (41.9%)
Ongoing
2 (6.5%)

Trenbolone Acetate + Estradiol Adverse Event Insights

19 reports name Trenbolone Acetate + Estradiol; 16 recorded a death outcome (84.2% of reported events, not a population-level mortality rate). Active ingredient: Trenbolone Acetate + Estradiol. Administration routes: Unknown, Topical, Other, Parenteral.

By species: Cattle (19 reports). By breed: Cattle (unknown) (10), Cattle (other) (4), Crossbred Bovine/Cattle (3).

Leading clinical signs: Death (15), Digestive tract disorder NOS (8), Respiratory tract disorder NOS (7), Bloated (5). Outcome, 31 coded reports: Died leads at 51.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.