Drug profile

The FDA adverse-event record for Tobramycin Ophthalmic

33 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Tobramycin Ophthalmic. See the species affected, top reactions, and outcomes below.

33
adverse-event reports
12.1%
death-coded share
Dog
most-reported species
6
Tympanic rupture - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
33
Total Reports
4
Deaths Reported
12.1%
Death Rate

Active Ingredients

Tobramycin Ophthalmic

Administration Routes

OphthalmicUnknownIntraocularTopical

Species Affected

Dog 19
Cat 14

Most Affected Breeds

Domestic Shorthair 6
Domestic Mediumhair 4
Bichon Frise 3
Saint Bernard Dog 3
Dog (unknown) 2
Shih Tzu 2
Poodle - Miniature 2
Pug 1
Terrier - Boston 1
Pekingese 1

Most Reported Reactions

Tympanic rupture 6
Anorexia 5
Not eating 5
Hypersalivation 5
Dehydration 5
Not drinking 5
Ocular discharge 4
Ataxia 4
Corneal ulcer 4
Ear infection NOS 4
Vomiting 4
Behavioural disorder NOS 4

Outcome Breakdown

Ongoing
20 (60.6%)
Outcome Unknown
6 (18.2%)
Recovered/Normal
3 (9.1%)
Died
2 (6.1%)
Euthanized
2 (6.1%)

Tobramycin Ophthalmic Adverse Event Insights

33 reports name Tobramycin Ophthalmic; 4 recorded a death outcome (12.1% of reported events, not a population-level mortality rate). Active ingredient: Tobramycin Ophthalmic. Administration routes: Ophthalmic, Unknown, Intraocular, Topical.

By species: Dog (19 reports), Cat (14 reports). By breed: Domestic Shorthair (6), Domestic Mediumhair (4), Bichon Frise (3).

Leading clinical signs: Tympanic rupture (6), Anorexia (5), Not eating (5), Hypersalivation (5). Outcome, 33 coded reports: Ongoing leads at 60.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.