Drug profile

The FDA adverse-event record for Sodium Bicarbonate

13 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Sodium Bicarbonate. See the species affected, top reactions, and outcomes below.

13
adverse-event reports
38.5%
death-coded share
Dog
most-reported species
3
Death - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
13
Total Reports
5
Deaths Reported
38.5%
Death Rate

Active Ingredients

Sodium Bicarbonate

Administration Routes

OralUnknownParenteralOtherIntravenous

Species Affected

Dog 7
Cattle 3
Cat 3

Most Affected Breeds

Terrier - Jack Russell 2
Basenji 1
Cattle (other) 1
Collie - Border 1
Bulldog 1
Domestic (unspecified) 1
Holstein-Friesian also known as Holstein 1
Aberdeen Angus 1
Domestic Shorthair 1
Retriever - Labrador 1

Most Reported Reactions

Death 3
Vomiting 3
Seizure NOS 2
Not eating 2
Lack of efficacy - NOS 2
Lack of efficacy (ectoparasite) - flea 2
Elevated blood urea nitrogen (BUN) 2
Lethargy (see also Central nervous system depression in 'Neurological') 2
Behavioural disorder NOS 2
Death by euthanasia 2
Anorexia 2
Dehydration 2

Outcome Breakdown

Recovered/Normal
3 (21.4%)
Ongoing
3 (21.4%)
Died
3 (21.4%)
Outcome Unknown
3 (21.4%)
Euthanized
2 (14.3%)

Sodium Bicarbonate Adverse Event Insights

13 reports name Sodium Bicarbonate; 5 recorded a death outcome (38.5% of reported events, not a population-level mortality rate). Active ingredient: Sodium Bicarbonate. Administration routes: Oral, Unknown, Parenteral, Other.

By species: Dog (7 reports), Cattle (3 reports), Cat (3 reports). By breed: Terrier - Jack Russell (2), Basenji (1), Cattle (other) (1).

Leading clinical signs: Death (3), Vomiting (3), Seizure NOS (2), Not eating (2). Outcome, 14 coded reports: Recovered/Normal leads at 21.4%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.