Drug profile

The FDA adverse-event record for Sentinel Spectrum

40 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Sentinel Spectrum. See the species affected, top reactions, and outcomes below.

40
adverse-event reports
15.0%
death-coded share
Dog
most-reported species
18
Lack of efficacy (endoparasite) - heartworm - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
40
Total Reports
6
Deaths Reported
15.0%
Death Rate

Active Ingredients

Sentinel Spectrum

Administration Routes

OralUnknown

Species Affected

Dog 40

Most Affected Breeds

Retriever - Labrador 4
Retriever - Golden 3
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 3
Hound (unspecified) 2
Dachshund (unspecified) 2
Boxer (German Boxer) 2
Crossbred Canine/dog 2
Shepherd Dog - German 2
Coton de Tuléar 1
Terrier - Bull - Staffordshire 1

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 18
Vomiting 6
Diarrhoea 4
Death 4
Seizure NOS 4
Lethargy (see also Central nervous system depression in Neurological) 4
Anaemia NOS 4
Not eating 4
Other abnormal test result NOS 3
Polydipsia 3
Decreased appetite 2
Agitation 2

Outcome Breakdown

Ongoing
26 (65.0%)
Outcome Unknown
7 (17.5%)
Died
4 (10.0%)
Euthanized
2 (5.0%)
Recovered/Normal
1 (2.5%)

Sentinel Spectrum Adverse Event Insights

40 reports name Sentinel Spectrum; 6 recorded a death outcome (15.0% of reported events, not a population-level mortality rate). Active ingredient: Sentinel Spectrum. Administration routes: Oral, Unknown.

By species: Dog (40 reports). By breed: Retriever - Labrador (4), Retriever - Golden (3), Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) (3).

Leading clinical signs: Lack of efficacy (endoparasite) - heartworm (18), Vomiting (6), Diarrhoea (4), Death (4). Outcome, 40 coded reports: Ongoing leads at 65.0%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.