Drug profile

The FDA adverse-event record for Sedation

26 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Sedation. Species, reactions, and outcomes follow.

#1571 of 2,679
by report volume (all drugs)
26
adverse-event reports
15.4%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Sedation ranks #1543 of 2679 by total reports (26). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1543
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Sedation has 26 reports now versus 24 in that prior snapshot: 2 more (8.3%).

Report change
+2
Death-coded reports
+0
Death-coded share
−1.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Sedation changes

Signature read: death-coded share at 15.4% is the most distinctive stamp on Sedation's FDA AER row.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
26
Total Reports
4
Deaths Reported
15.4%
Death-coded share of reports

Active Ingredients

Sedation

Administration Routes

Unknown

Species Affected

Dog 18
Cat 7
Horse 1

Most Affected Breeds

Domestic Shorthair 4
Beagle 2
Rottweiler 1
Coton de Tuléar 1
Alaskan Malamute 1
Elkhound (unspecified) 1
Dog (unknown) 1
Mastiff 1
Domestic Mediumhair 1
Pug 1

Most Reported Reactions

Diarrhoea 5
Lethargy (see also Central nervous system depression in 'Neurological') 4
Weight loss 4
Vomiting 4
Head tilt - ear disorder 4
Emesis 3
Death by euthanasia 3
Anorexia 3
Horner's syndrome 3
Elevated alanine aminotransferase (ALT) 2
Neurological symptoms NOS 2
Application site erythema 2

Outcome Breakdown

Outcome Unknown
9 (34.6%)
Recovered/Normal
8 (30.8%)
Ongoing
5 (19.2%)
Euthanized
3 (11.5%)
Died
1 (3.8%)

Sedation Adverse Event Insights

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Sedation (#1571 of 2,679 by report volume); death-coded 15.4%. PlainBreed drug row · death-coded share stamp 15.4% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →