Drug profile

The FDA adverse-event record for Same And Silybin

44 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Same And Silybin. Species, reactions, and outcomes follow.

#1208 of 2,679
by report volume (all drugs)
44
adverse-event reports
22.7%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Same And Silybin ranks #1198 of 2679 by total reports (44). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1198
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Same And Silybin has 44 reports now versus 43 in that prior snapshot: 1 more (2.3%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Same And Silybin changes

Signature read: Same And Silybin's 22.7% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
44
Total Reports
10
Deaths Reported
22.7%
Death-coded share of reports

Active Ingredients

Same And Silybin

Administration Routes

OralUnknown

Species Affected

Dog 43
Cat 1

Most Affected Breeds

Chihuahua 6
Terrier - Yorkshire 3
Maltese 3
Retriever - Labrador 3
Dog (unknown) 3
Terrier (unspecified) 3
Poodle - Standard 2
Dog (other) 2
Crossbred Canine/dog 2
Dachshund - Standard Long-haired 1

Most Reported Reactions

Weight loss 11
Elevated serum alkaline phosphatase (SAP) 10
Elevated alanine aminotransferase (ALT) 10
Diarrhoea 10
Lack of efficacy - NOS 10
Abnormal adrenocorticotropic hormone (ACTH) stimulation test 9
INEFFECTIVE, CUSHINGS 7
Abnormal ultrasound finding 7
Elevated gamma-glutamyl transferase (GGT) 6
Death by euthanasia 6
Proteinuria 6
Decreased appetite 6

Outcome Breakdown

Outcome Unknown
21 (47.7%)
Ongoing
9 (20.5%)
Euthanized
7 (15.9%)
Recovered/Normal
4 (9.1%)
Died
3 (6.8%)

Same And Silybin: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Same And Silybin (#1208 of 2,679 by report volume); death-coded 22.7%. PlainBreed drug row · death-coded share stamp 22.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →