Drug profile

The FDA adverse-event record for Same And Silybin

41 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Same And Silybin. See the species affected, top reactions, and outcomes below.

41
adverse-event reports
24.4%
death-coded share
Dog
most-reported species
11
Weight loss - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
41
Total Reports
10
Deaths Reported
24.4%
Death Rate

Active Ingredients

Same And Silybin

Administration Routes

OralUnknown

Species Affected

Dog 40
Cat 1

Most Affected Breeds

Chihuahua 5
Terrier - Yorkshire 3
Maltese 3
Dog (unknown) 3
Terrier (unspecified) 3
Poodle - Standard 2
Crossbred Canine/dog 2
Dog (other) 2
Dachshund - Standard Long-haired 1
Pug 1

Most Reported Reactions

Weight loss 11
Elevated serum alkaline phosphatase (SAP) 10
Elevated alanine aminotransferase (ALT) 9
Diarrhoea 9
Abnormal adrenocorticotropic hormone (ACTH) stimulation test 8
Lack of efficacy - NOS 8
INEFFECTIVE, CUSHINGS 7
Elevated gamma-glutamyl transferase (GGT) 6
Death by euthanasia 6
Proteinuria 6
Decreased appetite 6
Abnormal ultrasound finding 6

Outcome Breakdown

Outcome Unknown
20 (48.8%)
Ongoing
7 (17.1%)
Euthanized
7 (17.1%)
Recovered/Normal
4 (9.8%)
Died
3 (7.3%)

Same And Silybin Adverse Event Insights

41 reports name Same And Silybin; 10 recorded a death outcome (24.4% of reported events, not a population-level mortality rate). Active ingredient: Same And Silybin. Administration routes: Oral, Unknown.

By species: Dog (40 reports), Cat (1 reports). By breed: Chihuahua (5), Terrier - Yorkshire (3), Maltese (3).

Leading clinical signs: Weight loss (11), Elevated serum alkaline phosphatase (SAP) (10), Elevated alanine aminotransferase (ALT) (9), Diarrhoea (9). Outcome, 41 coded reports: Outcome Unknown leads at 48.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.