S-Adenosyl-Methionine (Same) + Silybin
19 adverse event reports submitted to the FDA
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
19
Total Reports
3
Deaths Reported
1580.0%
Death Rate
Active Ingredients
S-Adenosyl-Methionine (Same) + Silybin
Administration Routes
OralTopical
Species Affected
Dog 19
Most Affected Breeds
Terrier - Boston 2
Poodle - Miniature 2
Shih Tzu 2
Dachshund - Miniature 1
Brittany 1
Dog (other) 1
Schnauzer - Miniature 1
Crossbred Canine/dog 1
Retriever - Golden 1
Chihuahua 1
Most Reported Reactions
Lethargy (see also Central nervous system depression in 'Neurological') 10
Elevated serum alkaline phosphatase (SAP) 5
Decreased appetite 5
Anorexia 5
Diarrhoea 4
Hyperglycaemia 4
Elevated alanine aminotransferase (ALT) 3
Elevated blood urea nitrogen (BUN) 3
Hyponatremia 3
Elevated liver enzymes 3
Death by euthanasia 3
Underdose 3
Outcome Breakdown
Outcome Unknown
13 (68.4%)
Recovered/Normal
3 (15.8%)
Euthanized
3 (15.8%)
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.