Drug profile

The FDA adverse-event record for S-Adenosyl-Methionine (Same)

33 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference S-Adenosyl-Methionine (Same). See the species affected, top reactions, and outcomes below.

33
adverse-event reports
15.2%
death-coded share
Dog
most-reported species
10
Elevated serum alkaline phosphatase (SAP) - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
33
Total Reports
5
Deaths Reported
15.2%
Death Rate

Active Ingredients

S-Adenosyl-Methionine (Same)

Administration Routes

Oral

Species Affected

Dog 32
Cat 1

Most Affected Breeds

Chihuahua 5
Shih Tzu 3
Dachshund - Miniature 2
Shepherd Dog - German 2
Terrier - Boston 2
Siberian Husky 1
Bulldog 1
Dachshund - Standard Long-haired 1
Terrier - Kerry Blue 1
Sheepdog - Shetland 1

Most Reported Reactions

Elevated serum alkaline phosphatase (SAP) 10
Lethargy (see also Central nervous system depression in 'Neurological') 8
Decreased appetite 7
Weight loss 6
Diarrhoea 6
Elevated blood urea nitrogen (BUN) 6
Hyperkalaemia 6
Anorexia 5
Elevated creatinine 5
Shaking 4
Vomiting 4
Lack of efficacy - NOS 4

Outcome Breakdown

Outcome Unknown
20 (60.6%)
Ongoing
5 (15.2%)
Recovered/Normal
3 (9.1%)
Died
3 (9.1%)
Euthanized
2 (6.1%)

S-Adenosyl-Methionine (Same) Adverse Event Insights

33 reports name S-Adenosyl-Methionine (Same); 5 recorded a death outcome (15.2% of reported events, not a population-level mortality rate). Active ingredient: S-Adenosyl-Methionine (Same). Administration route: Oral.

By species: Dog (32 reports), Cat (1 reports). By breed: Chihuahua (5), Shih Tzu (3), Dachshund - Miniature (2).

Leading clinical signs: Elevated serum alkaline phosphatase (SAP) (10), Lethargy (see also Central nervous system depression in 'Neurological') (8), Decreased appetite (7), Weight loss (6). Outcome, 33 coded reports: Outcome Unknown leads at 60.6%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.