Drug profile

The FDA adverse-event record for Procaine Penicillin G

21 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Procaine Penicillin G. See the species affected, top reactions, and outcomes below.

21
adverse-event reports
23.8%
death-coded share
Cat
most-reported species
4
Vomiting - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
21
Total Reports
5
Deaths Reported
23.8%
Death Rate

Active Ingredients

Procaine Penicillin G

Administration Routes

UnknownIntramuscularSubcutaneousOral

Species Affected

Cat 10
Dog 6
Cattle 3
Horse 2

Most Affected Breeds

Domestic Shorthair 7
Unknown 2
Retriever - Labrador 2
Domestic Longhair 2
Terrier - Airedale 1
Schnauzer (unspecified) 1
Dachshund (unspecified) 1
Paint 1
Cattle (other) 1
Rex - Devon 1

Most Reported Reactions

Vomiting 4
Hyperactivity 4
Anaemia NOS 3
Elevated alanine aminotransferase (ALT) 3
Elevated serum alkaline phosphatase (SAP) 3
Death by euthanasia 3
Diarrhoea 3
Eye disorder NOS (for photophobia see 'neurological') 2
Hyperphosphataemia 2
Unable to stand 2
Other abnormal test result NOS 2
Weakness 2

Outcome Breakdown

Ongoing
8 (38.1%)
Recovered/Normal
6 (28.6%)
Euthanized
3 (14.3%)
Outcome Unknown
2 (9.5%)
Died
2 (9.5%)

Procaine Penicillin G Adverse Event Insights

21 reports name Procaine Penicillin G; 5 recorded a death outcome (23.8% of reported events, not a population-level mortality rate). Active ingredient: Procaine Penicillin G. Administration routes: Unknown, Intramuscular, Subcutaneous, Oral.

By species: Cat (10 reports), Dog (6 reports), Cattle (3 reports). By breed: Domestic Shorthair (7), Unknown (2), Retriever - Labrador (2).

Leading clinical signs: Vomiting (4), Hyperactivity (4), Anaemia NOS (3), Elevated alanine aminotransferase (ALT) (3). Outcome, 21 coded reports: Ongoing leads at 38.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.