Drug profile

The FDA adverse-event record for Prazosin Hcl

38 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Prazosin Hcl. See the species affected, top reactions, and outcomes below.

38
adverse-event reports
23.7%
death-coded share
Cat
most-reported species
10
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
38
Total Reports
9
Deaths Reported
23.7%
Death Rate

Active Ingredients

Prazosin Hcl

Administration Routes

UnknownOral

Species Affected

Cat 32
Dog 6

Most Affected Breeds

Domestic Shorthair 20
Domestic Longhair 4
Domestic Mediumhair 4
Cat (other) 2
Boxer (German Boxer) 1
Terrier - Bull - American Pit 1
Dachshund (unspecified) 1
Retriever - Golden 1
Beagle 1
Shepherd Dog - Belgian Malinois 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 10
Death by euthanasia 8
Seizure NOS 7
Anorexia 7
Vomiting 7
Anaemia NOS 6
Fever 6
Dilated pupils 5
Elevated blood urea nitrogen (BUN) 5
Hypersalivation 4
Other abnormal test result NOS 4
Elevated creatinine 4

Outcome Breakdown

Ongoing
25 (64.1%)
Euthanized
6 (15.4%)
Died
3 (7.7%)
Outcome Unknown
3 (7.7%)
Recovered/Normal
2 (5.1%)

Prazosin Hcl Adverse Event Insights

38 reports name Prazosin Hcl; 9 recorded a death outcome (23.7% of reported events, not a population-level mortality rate). Active ingredient: Prazosin Hcl. Administration routes: Unknown, Oral.

By species: Cat (32 reports), Dog (6 reports). By breed: Domestic Shorthair (20), Domestic Longhair (4), Domestic Mediumhair (4).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (10), Death by euthanasia (8), Seizure NOS (7), Anorexia (7). Outcome, 39 coded reports: Ongoing leads at 64.1%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.