Drug profile

The FDA adverse-event record for Polyethylene Glycol 3350

39 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Polyethylene Glycol 3350. Species, reactions, and outcomes follow.

#1277 of 2,679
by report volume (all drugs)
39
adverse-event reports
20.5%
death-coded share
Cat
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Polyethylene Glycol 3350 ranks #1263 of 2679 by total reports (39). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1263
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Polyethylene Glycol 3350 has 39 reports now versus 33 in that prior snapshot: 6 more (18.2%).

Report change
+6
Death-coded reports
+3
Death-coded share
+5.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Polyethylene Glycol 3350 changes

Signature read: Polyethylene Glycol 3350's 20.5% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
39
Total Reports
8
Deaths Reported
20.5%
Death-coded share of reports

Active Ingredients

Polyethylene Glycol 3350

Administration Routes

OralUnknown

Species Affected

Cat 38
Human 1

Most Affected Breeds

Domestic Shorthair 22
Domestic Longhair 6
Cat (unknown) 2
Scottish Fold Shorthair 1
American Bobtail 1
Domestic Mediumhair 1
Unknown 1
Tonkinese 1
Russian 1
Siamese 1

Most Reported Reactions

Lack of efficacy - NOS 6
Death 5
Vomiting 5
Decreased appetite 4
Behavioural disorder NOS 4
Intentional misuse 4
Death by euthanasia 3
Vocalisation 3
Diarrhoea 3
Decreased bowel movements 3
Weight loss 3
Not eating 3

Outcome Breakdown

Recovered/Normal
15 (38.5%)
Ongoing
11 (28.2%)
Outcome Unknown
5 (12.8%)
Died
5 (12.8%)
Euthanized
3 (7.7%)

Polyethylene Glycol 3350: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Polyethylene Glycol 3350 (#1277 of 2,679 by report volume); death-coded 20.5%. PlainBreed drug row · death-coded share stamp 20.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →