Drug profile

The FDA adverse-event record for Petrolatum, Mineral Oil

21 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Petrolatum, Mineral Oil. See the species affected, top reactions, and outcomes below.

21
adverse-event reports
14.3%
death-coded share
Cat
most-reported species
6
Lethargy (see also Central nervous system depression in 'Neurological') - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
21
Total Reports
3
Deaths Reported
14.3%
Death Rate

Active Ingredients

Petrolatum, Mineral Oil

Administration Routes

OralUnknown

Species Affected

Cat 19
Dog 2

Most Affected Breeds

Domestic Shorthair 6
Siamese 3
Maine Coon 2
Domestic Longhair 2
Domestic Mediumhair 2
Burmese 1
Retriever - Golden 1
Himalayan 1
Manx 1
Cat (other) 1

Most Reported Reactions

Lethargy (see also Central nervous system depression in 'Neurological') 6
Constipation 5
Lack of efficacy - NOS 3
Lack of efficacy (bacteria) - NOS 3
Vocalisation 3
Not eating 3
Behavioural disorder NOS 3
Weight loss 3
Vomiting 3
Drooling 2
Ataxia 2
Other abnormal test result NOS 2

Outcome Breakdown

Ongoing
14 (66.7%)
Died
3 (14.3%)
Outcome Unknown
3 (14.3%)
Recovered/Normal
1 (4.8%)

Petrolatum, Mineral Oil Adverse Event Insights

21 reports name Petrolatum, Mineral Oil; 3 recorded a death outcome (14.3% of reported events, not a population-level mortality rate). Active ingredient: Petrolatum, Mineral Oil. Administration routes: Oral, Unknown.

By species: Cat (19 reports), Dog (2 reports). By breed: Domestic Shorthair (6), Siamese (3), Maine Coon (2).

Leading clinical signs: Lethargy (see also Central nervous system depression in 'Neurological') (6), Constipation (5), Lack of efficacy - NOS (3), Lack of efficacy (bacteria) - NOS (3). Outcome, 21 coded reports: Ongoing leads at 66.7%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.