Drug profile

The FDA adverse-event record for Penicillin G Potassium

21 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Penicillin G Potassium. See the species affected, top reactions, and outcomes below.

21
adverse-event reports
14.3%
death-coded share
Unknown
most-reported species
2
Containers, Damaged - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
21
Total Reports
3
Deaths Reported
14.3%
Death Rate

Active Ingredients

Penicillin G Potassium

Administration Routes

UnknownIntravenousSubcutaneous

Species Affected

Unknown 7
Dog 6
Horse 4
Pig 2
Cat 2

Most Affected Breeds

Unknown 9
Quarter Horse 4
Terrier - Bull - American Pit 2
Domestic Shorthair 2
Coton de Tuléar 1
Shiba Inu 1
Terrier - Jack Russell 1
Retriever - Labrador 1

Most Reported Reactions

Containers, Damaged 2
Containers, Leaking 2
Seizure NOS 2
Cold feeling of extremity 2
Tachycardia 2
Tachypnoea 2
Diarrhoea 2
Partial adipsia 2
Decreased appetite 2
Death by euthanasia 2
Underfilling, Package 1
Collapse NOS (see also 'Cardio-vascular' and 'Neurological disorders') 1

Outcome Breakdown

Recovered/Normal
6 (42.9%)
Ongoing
5 (35.7%)
Euthanized
2 (14.3%)
Died
1 (7.1%)

Penicillin G Potassium Adverse Event Insights

21 reports name Penicillin G Potassium; 3 recorded a death outcome (14.3% of reported events, not a population-level mortality rate). Active ingredient: Penicillin G Potassium. Administration routes: Unknown, Intravenous, Subcutaneous.

By species: Unknown (7 reports), Dog (6 reports), Horse (4 reports). By breed: Unknown (9), Quarter Horse (4), Terrier - Bull - American Pit (2).

Leading clinical signs: Containers, Damaged (2), Containers, Leaking (2), Seizure NOS (2), Cold feeling of extremity (2). Outcome, 14 coded reports: Recovered/Normal leads at 42.9%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.