Drug profile

The FDA adverse-event record for Nitrofurantoin

Name: Nitrofurantoin - FDA Animal Adverse Event Reports
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

13 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Nitrofurantoin. See the species affected, top reactions, and outcomes below.

13
adverse-event reports: 69.2%
death-coded share: Dog
most-reported species: 8
Death by euthanasia - top reaction

Compiled by PlainBreed Editorial, Pet Health Editorial Team

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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.

Total Reports

Deaths Reported

69.2%

Death Rate

Active Ingredients

Nitrofurantoin

Administration Routes

OralUnknown

Species Affected

Dog 10

Cat 2

Human 1

Most Affected Breeds

Domestic Shorthair 2

Dog (unknown) 2

Terrier (unspecified) 2

Shepherd Dog - German 1

Siberian Husky 1

Collie (unspecified) 1

Spaniel - King Charles Cavalier 1

Unknown 1

Bulldog 1

Retriever - Labrador 1

Most Reported Reactions

Death by euthanasia 8

Weight loss 3

Vomiting 2

Lethargy (see also Central nervous system depression in 'Neurological') 2

Behavioural disorder NOS 2

Ataxia 2

Hind limb paresis 2

Haemorrhage NOS 2

Collapse NOS (see also Cardio-vascular and Neurological disorders) 2

Agonal breathing 2

Decreased haematocrit 2

Sudden death 1

Outcome Breakdown

Euthanized

8 (61.5%)

Ongoing

2 (15.4%)

Recovered/Normal

2 (15.4%)

Died

1 (7.7%)

Nitrofurantoin Adverse Event Insights

13 reports name Nitrofurantoin; 9 recorded a death outcome (69.2% of reported events, not a population-level mortality rate). Active ingredient: Nitrofurantoin. Administration routes: Oral, Unknown.

By species: Dog (10 reports), Cat (2 reports), Human (1 reports). By breed: Domestic Shorthair (2), Dog (unknown) (2), Terrier (unspecified) (2).

Leading clinical signs: Death by euthanasia (8), Weight loss (3), Vomiting (2), Lethargy (see also Central nervous system depression in 'Neurological') (2). Outcome, 13 coded reports: Euthanized leads at 61.5%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.