Drug profile

The FDA adverse-event record for Mannheimia Haemolytica, Strain Nl-1009;Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1

44 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Mannheimia Haemolytica, Strain Nl-1009;Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1. See the species affected, top reactions, and outcomes below.

44
adverse-event reports
93.2%
death-coded share
Cattle
most-reported species
36
Death - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
44
Total Reports
41
Deaths Reported
93.2%
Death Rate

Active Ingredients

Mannheimia Haemolytica, Strain Nl-1009;Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1

Administration Routes

Subcutaneous

Species Affected

Cattle 44

Most Affected Breeds

Mixed (Cattle) 35
Aberdeen Angus 4
Brangus 2
Red Angus 1
Piedmont 1
Jersey 1

Most Reported Reactions

Death 36
Lack of efficacy - NOS 30
Anaphylaxis 4
Found dead 4
Lack of efficacy (bacteria) - Mannheimia haemolytica 4
Lack of efficacy (mycoplasma) - NOS 3
Lack of efficacy (bacteria) - Histophilus somni 3
Necropsy performed 2
Bloody foam in mouth and nose 1
Anaphylactic-type reaction 1
Lack of efficacy (virus) - NOS 1
Death by euthanasia 1

Outcome Breakdown

Died
41 (53.2%)
Outcome Unknown
18 (23.4%)
Ongoing
9 (11.7%)
Recovered/Normal
7 (9.1%)
Euthanized
2 (2.6%)

Mannheimia Haemolytica, Strain Nl-1009;Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Adverse Event Insights

44 reports name Mannheimia Haemolytica, Strain Nl-1009;Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1; 41 recorded a death outcome (93.2% of reported events, not a population-level mortality rate). Active ingredient: Mannheimia Haemolytica, Strain Nl-1009;Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1. Administration route: Subcutaneous.

By species: Cattle (44 reports). By breed: Mixed (Cattle) (35), Aberdeen Angus (4), Brangus (2).

Leading clinical signs: Death (36), Lack of efficacy - NOS (30), Anaphylaxis (4), Found dead (4). Outcome, 77 coded reports: Died leads at 53.2%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.