Drug profile

The FDA adverse-event record for Lyme,Leptospirosis Vaccine

16 FDA reports name Lyme,Leptospirosis Vaccine, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#2034 of 2,679
by report volume (all drugs)
16
adverse-event reports
6.3%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Lyme,Leptospirosis Vaccine ranks #1995 of 2679 by total reports (16). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1995
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lyme,Leptospirosis Vaccine has 16 reports now versus 16 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lyme,Leptospirosis Vaccine changes

Signature read: 16 reports place Lyme,Leptospirosis Vaccine in the lower third of FDA AER volume (#2034 of 2,679).

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
16
Total Reports
1
Deaths Reported
6.3%
Death-coded share of reports

Active Ingredients

Lyme,Leptospirosis Vaccine

Administration Routes

UnknownSubcutaneous

Species Affected

Dog 16

Most Affected Breeds

Retriever - Labrador 5
Crossbred Canine/dog 2
Corgi - Welsh Cardigan 1
Pit Bull 1
American Pit Bull Terrier 1
Lhasa Apso 1
Coton de Tuléar 1
Shih Tzu 1
Weimaraner 1
Pointing Dog - German Short-haired 1

Most Reported Reactions

Lack of efficacy (endoparasite) - heartworm 5
Other abnormal test result NOS 5
Vomiting 3
Mucous stool 3
Pasty stool 3
Urinary incontinence 3
Lack of efficacy (endoparasite) - hookworm 3
Lack of efficacy (bacteria) - Borrelia 2
Lack of efficacy (ectoparasite) - tick NOS 2
Lack of efficacy (endoparasite) - whipworm 2
Pica NOS 2
Allergy NOS 2

Outcome Breakdown

Outcome Unknown
7 (43.8%)
Ongoing
7 (43.8%)
Recovered/Normal
1 (6.3%)
Euthanized
1 (6.3%)

Lyme,Leptospirosis Vaccine: lower report volume in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lyme,Leptospirosis Vaccine (#2034 of 2,679 by report volume); death-coded 6.3%. PlainBreed drug row · report volume stamp 16 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →