Drug profile

The FDA adverse-event record for Loperamide Hcl

34 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Loperamide Hcl. Species, reactions, and outcomes follow.

#1359 of 2,679
by report volume (all drugs)
34
adverse-event reports
26.5%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Loperamide Hcl ranks #1344 of 2679 by total reports (34). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1344
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Loperamide Hcl has 34 reports now versus 34 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Loperamide Hcl changes

Signature read: Loperamide Hcl's 26.5% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
34
Total Reports
9
Deaths Reported
26.5%
Death-coded share of reports

Active Ingredients

Loperamide Hcl

Administration Routes

UnknownOral

Species Affected

Dog 33
Cat 1

Most Affected Breeds

Retriever - Labrador 3
Mixed (Dog) 3
Shepherd Dog - German 3
Retriever - Golden 3
Terrier - Yorkshire 2
Shih Tzu 2
Schnauzer - Miniature 2
Bulldog 2
Pug 1
Bichon Frise 1

Most Reported Reactions

Diarrhoea 20
Vomiting 11
Lethargy (see also Central nervous system depression in 'Neurological') 10
Weight loss 7
Anorexia 6
Anaemia NOS 5
Blood in faeces 4
Fever 4
Death 4
Dehydration 4
Hypoalbuminaemia 4
Constipation 3

Outcome Breakdown

Ongoing
18 (50.0%)
Died
6 (16.7%)
Recovered/Normal
5 (13.9%)
Outcome Unknown
4 (11.1%)
Euthanized
3 (8.3%)

Loperamide Hcl: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Loperamide Hcl (#1359 of 2,679 by report volume); death-coded 26.5%. PlainBreed drug row · death-coded share stamp 26.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →