Drug profile

The FDA adverse-event record for Liver Support Supplement

17 FDA reports name Liver Support Supplement, a lower-volume drug in the CVM extract. Species, reactions, and outcomes follow.

#1977 of 2,679
by report volume (all drugs)
17
adverse-event reports
0.0%
death-coded share
Dog
most-reported species
Verify with FDA CVM →

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Liver Support Supplement ranks #1937 of 2679 by total reports (17). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1937
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Liver Support Supplement has 17 reports now versus 17 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Liver Support Supplement changes

Signature read: Liver Support Supplement's 0.0% death-coded share is among the lowest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
17
Total Reports
0
Deaths Reported
0.0%
Death-coded share of reports

Active Ingredients

Liver Support Supplement

Administration Routes

OralUnknownOther

Species Affected

Dog 17

Most Affected Breeds

Chihuahua 3
Shih Tzu 2
Retriever - Labrador 2
Terrier - Cairn 1
Beagle 1
Shepherd Dog - Anatolian 1
Sheepdog - Old English 1
Retriever - Golden 1
Boxer (German Boxer) 1
Crossbred Canine/dog 1

Most Reported Reactions

Lack of efficacy - NOS 3
Vomiting 3
Star-gazing 2
Lack of efficacy (endoparasite) - heartworm 2
Elevated serum alkaline phosphatase (SAP) 2
Elevated alanine aminotransferase (ALT) 2
Diarrhoea 2
Urinary tract infection 2
Tiredness 1
Lethargy (see also Central nervous system depression in 'Neurological') 1
Disorientation 1
Lip smacking 1

Outcome Breakdown

Outcome Unknown
8 (47.1%)
Ongoing
6 (35.3%)
Recovered/Normal
3 (17.6%)

Liver Support Supplement: low death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Liver Support Supplement (#1977 of 2,679 by report volume); death-coded 0.0%. PlainBreed drug row · death-coded share stamp 0.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →