Drug profile

The FDA adverse-event record for Levothyroxin

16 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Levothyroxin. See the species affected, top reactions, and outcomes below.

16
adverse-event reports
37.5%
death-coded share
Dog
most-reported species
3
Seizure NOS - top reaction
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Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
16
Total Reports
6
Deaths Reported
37.5%
Death Rate

Active Ingredients

Levothyroxin

Administration Routes

OralUnknown

Species Affected

Dog 16

Most Affected Breeds

Crossbred Canine/dog 3
Shepherd Dog - German 2
Boxer (German Boxer) 2
Dog (other) 1
Retriever - Labrador 1
Poodle - Miniature 1
Shih Tzu 1
Akita 1
Terrier - Bull - American Pit 1
Chihuahua 1

Most Reported Reactions

Seizure NOS 3
Death by euthanasia 3
Diarrhoea 2
Vomiting 2
Polyuria 2
Polydipsia 2
Inappropriate urination 2
Not eating 2
Dehydration 2
Behavioural disorder NOS 2
Difficulty standing 2
Balance problem 2

Outcome Breakdown

Ongoing
7 (43.8%)
Died
3 (18.8%)
Euthanized
3 (18.8%)
Recovered/Normal
2 (12.5%)
Outcome Unknown
1 (6.3%)

Levothyroxin Adverse Event Insights

16 reports name Levothyroxin; 6 recorded a death outcome (37.5% of reported events, not a population-level mortality rate). Active ingredient: Levothyroxin. Administration routes: Oral, Unknown.

By species: Dog (16 reports). By breed: Crossbred Canine/dog (3), Shepherd Dog - German (2), Boxer (German Boxer) (2).

Leading clinical signs: Seizure NOS (3), Death by euthanasia (3), Diarrhoea (2), Vomiting (2). Outcome, 16 coded reports: Ongoing leads at 43.8%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.