Drug profile

The FDA adverse-event record for Lactated Ringer&Apos;S Solution

40 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Lactated Ringer&Apos;S Solution. Species, reactions, and outcomes follow.

#1253 of 2,679
by report volume (all drugs)
40
adverse-event reports
27.5%
death-coded share
Dog
most-reported species

Corpus placement

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Lactated Ringer&Apos;S Solution ranks #1245 of 2679 by total reports (40). Death-coded-share rank requires at least 50 reports. National dual: Milbemycin Oxime + Spinosad is #1 of 2679 drugs by total adverse-event reports (149,624) at death-coded-share rank 965 of 1130 drugs with at least 50 reports (2.3%); separately, Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) is #1 highest death-coded share at 97.8% (report rank #821).

149,624
Milbemycin Oxime + Spinosad reports (#1)
97.8%
Atlantic Salmon Transgenic Whole (Opafp-Ghc2 Rdna Construct Inserted Into The A-Locus In The Eo-1A Lineage) death share (#1)
#1245
This drug, reports of 2679

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lactated Ringer&Apos;S Solution has 40 reports now versus 38 in that prior snapshot: 2 more (5.3%).

Report change
+2
Death-coded reports
+0
Death-coded share
−1.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lactated Ringer&Apos;S Solution changes

Signature read: Lactated Ringer&Apos;S Solution's 27.5% death-coded share is among the highest in the openFDA drug corpus.

Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
40
Total Reports
11
Deaths Reported
27.5%
Death-coded share of reports

Active Ingredients

Lactated Ringer&Apos;S Solution

Administration Routes

IntravenousSubcutaneousUnknownIntra-ArticularOther

Species Affected

Dog 23
Cat 12
Horse 3
Other Birds 1
Guinea Pig 1

Most Affected Breeds

Domestic Shorthair 8
Retriever - Golden 4
Pit Bull 3
Unknown 2
Crossbred Canine/dog 2
Boxer (German Boxer) 2
Schipperke 2
Trakehner 2
Rex - Devon 1
Mixed (Dog) 1

Most Reported Reactions

Vomiting 8
Hypersalivation 7
Death 6
Diarrhoea 6
Lethargy (see also Central nervous system depression in Neurological) 6
Death by euthanasia 5
Lack of efficacy - NOS 5
Ataxia 4
Lethargy (see also Central nervous system depression in 'Neurological') 4
Other abnormal test result NOS 4
Thrombocytopenia 4
Increased percentage reticulocytes 4

Outcome Breakdown

Recovered/Normal
14 (35.0%)
Outcome Unknown
8 (20.0%)
Ongoing
7 (17.5%)
Died
6 (15.0%)
Euthanized
5 (12.5%)

Lactated Ringer&Apos;S Solution: high death-coded share in the FDA AER row

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

What to do with this drug

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lactated Ringer&Apos;S Solution (#1253 of 2,679 by report volume); death-coded 27.5%. PlainBreed drug row · death-coded share stamp 27.5% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →