Drug profile

The FDA adverse-event record for Ivermectin And Pyrantel Pamoate

30 adverse-event reports submitted to the FDA Center for Veterinary Medicine reference Ivermectin And Pyrantel Pamoate. See the species affected, top reactions, and outcomes below.

30
adverse-event reports
10.0%
death-coded share
Dog
most-reported species
8
Diarrhoea - top reaction
Verify with FDA CVM →
Important: Adverse event reports do not establish that a drug caused or contributed to the event. Consult your veterinarian before making treatment decisions.
30
Total Reports
3
Deaths Reported
10.0%
Death Rate

Active Ingredients

Ivermectin And Pyrantel Pamoate

Administration Routes

UnknownOral

Species Affected

Dog 30

Most Affected Breeds

Shepherd Dog - German 4
Retriever - Labrador 3
Mountain Dog - Bernese 2
Beagle 2
Retriever - Chesapeake Bay 2
Rottweiler 2
Retriever - Golden 2
Terrier - Yorkshire 1
Collie - Smooth-haired 1
Siberian Husky 1

Most Reported Reactions

Diarrhoea 8
Vomiting 8
Lethargy (see also Central nervous system depression in 'Neurological') 6
Elevated alanine aminotransferase (ALT) 6
Weight loss 4
Other abnormal test result NOS 4
Lameness 4
Lethargy (see also Central nervous system depression in Neurological) 4
Erythema (for urticaria see Immune SOC) 3
Papule 3
Thrombocytopenia 3
Neutrophilia 3

Outcome Breakdown

Outcome Unknown
13 (43.3%)
Recovered/Normal
7 (23.3%)
Ongoing
7 (23.3%)
Died
2 (6.7%)
Euthanized
1 (3.3%)

Ivermectin And Pyrantel Pamoate Adverse Event Insights

30 reports name Ivermectin And Pyrantel Pamoate; 3 recorded a death outcome (10.0% of reported events, not a population-level mortality rate). Active ingredient: Ivermectin And Pyrantel Pamoate. Administration routes: Unknown, Oral.

By species: Dog (30 reports). By breed: Shepherd Dog - German (4), Retriever - Labrador (3), Mountain Dog - Bernese (2).

Leading clinical signs: Diarrhoea (8), Vomiting (8), Lethargy (see also Central nervous system depression in 'Neurological') (6), Elevated alanine aminotransferase (ALT) (6). Outcome, 30 coded reports: Outcome Unknown leads at 43.3%.

Read these counts as reporting volume, not risk: per our methodology, a widely-prescribed drug will rack up more raw FDA reports in a given year than a rarely-used one at an identical true rate, so we recommend comparing within similar-exposure products rather than across the full 2025 catalog.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.